Results 201 to 210 of about 1,849,986 (263)

Loss of DNA mismatch repair genes leads to acquisition of antibiotic resistance independent of secondary mutations. [PDF]

PLoS Genet
Bautista DE, Carr JF, Whitehead CR, Kostoch B, Mitchell AM.   +4 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Re-examining hidden fitness: Female preferences for long-path songs in zebra finches. [PDF]

PLoS One
Sahu PK, Deimeke MJ, Garcia AD, Stenstrom KH, Smeltz SML, Wang Y, Ratch J, Sturdy CB.   +7 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Life science research in extreme environments: a conversation with astronaut Jessica Meir. [PDF]

Commun Biol
europepmc   +1 more source

Comprehensive profiling of circRNAs reveals stimulus-specific networks and core regulators of cellular senescence. [PDF]

PLoS One
Ge M, Liu Z, Zhao X, Zhan X, Jiang S.
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Protective effect of cannabinoid type II receptor ligand on bleomycin-induced pulmonary fibrosis in mice. [PDF]

PLoS One
Cao C, Wang RL, Guo CX, Xu XW, Wei JH, Cheng WZ, Yu YZ, Shi JJ, Feng ZW, Chen Y.   +9 more
europepmc   +1 more source

Leveraging epileptic network understanding to improve targeted treatment. [PDF]

PLoS Biol
Niemeyer JE.
europepmc   +1 more source

Prevalence of Gastrointestinal Parasites in Wild Asian Elephants (<i>Elephas maximus</i>) at a National Park in Eastern Thailand. [PDF]

Biology (Basel)
Kaewchot S, Thongyuan S, Sripiboon S, Chaiyarat R, Yingyong P, Bunsermyos W, Jarudecha T, Sanyathitiseree P.   +7 more
europepmc   +1 more source