Results 211 to 220 of about 15,925,070 (360)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Paromomycin is a more effective selection agent than kanamycin in Arabidopsis harboring the neomycin phosphotransferase II transgene. [PDF]

PLoS One
Goodman CP, Padgett VN, Evans ER, von Arnim AG.   +3 more
europepmc   +1 more source

The Potential Importance of K Type Human Endogenous Retroviral Elements in Melanoma Biology

, 2013
Jianli Dong, Gengming Huang, Rasheen Imtiaz, Fangling Xu   +3 more
openalex   +2 more sources

Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer’s disease

, 2022
Chirag Gupta, Jielin Xu, Ting Jin, Saniya Khullar, Xiaoyu Liu, Sayali Alatkar, Feixiong Cheng, Daifeng Wang   +7 more
openalex   +2 more sources

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

Science, 2015
E. Blackburn, E. Epel, Jue Lin
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

The General Education Type of Biology Course [PDF]

The American Biology Teacher, 1953
openaire   +1 more source

CRISPR/Cas9-Mediated Knockout of the <i>Corazonin</i> Gene Indicates Its Regulation on the Cuticle Development of Desert Locusts (<i>Schistocerca gregaria</i>). [PDF]

Insects
He Y, Yan Q, Bi Y, Liu G, Hou S, Chen X, Zhao X, Zhang X, Zhang M, Zhang J, Ma B, Warren B, Roth S, Zhang T.   +13 more
europepmc   +1 more source

The outcome of allogeneic HSCT in older AML patients is determined by disease biology and not by the donor type: An analysis of 96 allografted AML patients ≥50 years from the Czech acute leukaemia clinical register (alert)

, 2013
Pavel Jindra, Jan Mužı́k, Karel Indrák, П. П. Зак, Firas Al Sabty, Tomáš Kozák, Petr Cetkovský, M. Karas V. Koza, Luděk Raida, Tomáš Szotkowski   +9 more
openalex   +2 more sources

The multifaceted biology of plasmacytoid dendritic cells

Nature reviews. Immunology, 2015
M. Swiecki, M. Colonna
semanticscholar   +1 more source