Results 81 to 90 of about 31,306,322 (385)

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

An overview of the qualitative descriptive design within nursing research

open access: yesJournal of Research in Nursing, 2019
Background Qualitative descriptive designs are common in nursing and healthcare research due to their inherent simplicity, flexibility and utility in diverse healthcare contexts.
L. Doyle   +4 more
semanticscholar   +1 more source

Fabula: type design [PDF]

open access: yes
Originally a screen font for the Fabula project in 2004-5 redesigned for print for Collins publishers for their children's dictionary ...
Connare, Vincent   +2 more
core  

Bridge type classification: supervised learning on a modified NBI dataset

open access: yes, 2017
A key phase in the bridge design process is the selection of the structural system. Due to budget and time constraints, engineers typically rely on engineering judgment and prior experience when selecting a structural system, often considering a limited ...
Jootoo, Achyuthan, Lattanzi, David
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

open access: yesFEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri   +5 more
wiley   +1 more source

Swedish Typo-Morphology – Morphological Conceptualizations and Implication for Urban Design

open access: yesIconarp International Journal of Architecture and Planning, 2019
Typo-morphology is a branch of urban morphology that understands physical form, formation and transformation in cities with use of types and typologies.
Todor Stojanovski
doaj   +1 more source

SMS design review plan, type 1 data [PDF]

open access: yes
The SMS PDR plan is submitted incrementally 15 days prior to the associated PDR's.

core   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

open access: yesFEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker   +9 more
wiley   +1 more source

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