Results 61 to 70 of about 2,088,428 (332)
Frontiers in Genetics, 2016 Regression analysis is commonly used in genome-wide association studies (GWAS) to test genotype-phenotype associations but restricts the phenotype to a single observation for each individual.
Marijana Vujkovic +4 more
doaj +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Type I and Type II error concerns in fMRI research: re-balancing the scale [PDF]
Social Cognitive and Affective Neuroscience, 2009 Statistical thresholding (i.e. P-values) in fMRI research has become increasingly conservative over the past decade in an attempt to diminish Type I errors (i.e. false alarms) to a level traditionally allowed in behavioral science research. In this article, we examine the unintended negative consequences of this single-minded devotion to Type I errors:
Matthew D, Lieberman +1 more
openaire +2 more sources
A note on error estimation for hypothesis testing problems for some linear SPDEs [PDF]
, 2013 The aim of the present paper is to estimate and control the Type I and Type II errors of a simple hypothesis testing problem of the drift/viscosity coefficient for stochastic fractional heat equation driven by additive noise.
Cialenco, Igor, Xu, Liaosha
core +2 more sources
, 2017 We theoretically investigate the damping and trapping forces in a three-dimensional magneto-optical trap (MOT), by numerically solving the optical Bloch equations. We focus on the case where there are dark states because the atom is driven on a "type-II"
Devlin, J. A., Tarbutt, M. R.
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
On the colour and spin of epistemic error (and what we might do about it) [PDF]
Hydrology and Earth System Sciences, 2011 Disinformation as a result of epistemic error is an issue in hydrological modelling. In particular the way in which the colour in model residuals resulting from epistemic errors should be expected to be non-stationary means that it is difficult to ...
K. Beven, P. J. Smith, A. Wood
doaj +1 more source
New normality test in high dimension with kernel methods [PDF]
, 2014 A new goodness-of-fit test for normality in high-dimension (and Reproducing Kernel Hilbert Space) is proposed. It shares common ideas with the Maximum Mean Discrepancy (MMD) it outperforms both in terms of computation time and applicability to a wider ...
Celisse, Alain, Kellner, Jérémie
core +3 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source