Results 81 to 90 of about 646,289 (312)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The In Situ Supermolecular Structure of Type I Collagen [PDF]

Structure, 2001
The proteins belonging to the collagen family are ubiquitous throughout the animal kingdom. The most abundant collagen, type I, readily forms fibrils that convey the principal mechanical support and structural organization in the extracellular matrix of connective tissues such as bone, skin, tendon, and vasculature.
Orgel, J P R O, Miller, Andrew, Irving, Thomas C, Fischetti, Robert F, Hammersley, Andrew P, Wess, Tim J   +5 more
openaire   +3 more sources

Hernia fibroblasts lack β-estradiol induced alterations of collagen gene expression

BMC Cell Biology, 2006
Background Estrogens are reported to increase type I and type III collagen deposition and to regulate Metalloproteinase 2 (MMP-2) expression. These proteins are reported to be dysregulated in incisional hernia formation resulting in a significantly ...
Junge Karsten, Mertens Peter R, Rezvani Melanie, Rosch Raphael, Jansen Petra, Jansen Marc, Klinge Uwe   +6 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Transdermal Delivery of Functional Collagen \u3cem\u3eVia\u3c/em\u3e Polyvinylpyrrolidone Microneedles [PDF]

, 2015
Collagen makes up a large proportion of the human body, particularly the skin. As the body ages, collagen content decreases, resulting in wrinkled skin and decreased wound healing capabilities.
Inayathullah, Mohammed, Lane, Alfred T., Malkovskiy, Andrey V., Manickam, Sathish, Manoukian, Martin A. C., Marinkovich, M. Peter, Rajadas, Jayakumar, Seifalian, Alexander M., Sun, Wenchao, Tayebi, Lobat   +9 more
core   +1 more source

Comparative Effectiveness of Structural versus Regulatory Protein Gene Transfer on Articular Chondrocyte Matrix Gene Expression [PDF]

, 2019
OBJECTIVE: The production of extracellular matrix is a necessary component of articular cartilage repair. Gene transfer is a promising method to improve matrix biosynthesis by articular chondrocytes.
Chan, Albert, Eckert, George J., Kirmani, Kashif, Shi, Shuiliang, Trippel, Stephen B., Wang, Congrong   +5 more
core   +1 more source

Gold nanoparticles coated with collagen-I and their wound healing activity in human skin fibroblast cells

Heliyon
The slow wound healing process has become a major health problem. Gold nanoparticles (AuNPs) have been used in various biomedical applications because of their unique properties.
Sasiprapa Poomrattanangoon, Dakrong Pissuwan   +1 more
doaj   +1 more source

The Effect of Aerobic Exercise on Collagen Type I and IV Gene Expression and Collagen Type I Protein Changes in the Sciatic Nerve of Diabetic Rats

Novelty in Biomedicine, 2020
Background: Neuropathy is one of the complications of diabetes, probably due to the destruction of the extracellular matrix and the thickening of the peripheral nerve basement membrane.
Nahid Jalilian Hamed, Reza Gharakhanlou, Maghsoud Peeri   +2 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Investigation of type I collagen deposition in the glomeruli of COL1A2 deficient mice [PDF]

, 2004
only availableType I collagen is the most abundant structural protein in the body, playing a major role in the strength and integrity of connective tissues.
Brodeur, Amanda C., 1978-, Howard, Allison, Pheiffer, Brent, Phillips, Charlotte L., Wirth, David   +4 more
core