Results 81 to 90 of about 387,781 (267)
Low‐Fraction Irregular Inclusions Trigger Large Compression Stiffening in Biopolymer Hydrogels
Advanced Functional Materials, EarlyView.Irregular inclusions at low filler fractions trigger large compression stiffening in biopolymer hydrogels. By promoting contact‐network formation under compression, these inclusions induce non‐affine rearrangements, stretch surrounding fibers, and provide parallel load‐bearing pathways.
Xuechen Shi +3 more
wiley +1 more source
Chemical Maturation Controls Bioavailability of Fetuin‐A‐Mineral Complexes in Biomineralization
Advanced Functional Materials, EarlyView.The role of Fetuin‐A‐mineral complexes in matrix mineralization is unclear. Here, Fetuin‐A‐mineral complexes were found to exist in functionally distinct states that determine mineral bioavailability: chemically labile calciprotein monomers directly mineralize collagen fibrils, while chemically matured primary calciprotein particles require cellular ...
Judith M. Schaart +8 more
wiley +1 more source
Type I Collagen degradation assay.
, 2015 Collagen degradation measured in culture supernatants from canine endothelial (A) and smooth muscle cells (B) untreated or treated with 10 μg/ml of PLG, 1 μg/ml of rDiACT/rDiFBAL, 1 μg/ml of rDiACT/rDiFBAL + 10 μg/ml of PLG or with 1 μg/ml of rDiACT ...
Rodrigo Morchón (721328) +3 more
core +1 more source
Regulatory Role of FGF-2 on Type I Collagen Expression during Endothelial Mesenchymal Transformation [PDF]
, 2020 PURPOSE. To investigate the regulatory role of FGF-2 on type I collagen expression during endothelial mesenchymal transformation (EMT). METHODS. Corneal endothelial cells (CECs) treated with FGF-2 from the primary culture to the third passage were ...
Eunduck P Kay, Minhee K Ko
core
Advanced Healthcare Materials, EarlyView.Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng +16 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Type I collagen-integrin interactions in angiogenesis
, 2010 Angiogenesis, the formation of new blood vessels by branching from existing vessels, is the primary mechanism for vascular extension in adults. Following injury or hypoxia, endothelial cells proteolytically degrade their basement membranes and encounter ...
Turner, Kevin, Turner, Kevin R
core
A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair
Advanced Healthcare Materials, EarlyView.An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret +6 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin +18 more
wiley +1 more source
DDR1 activation determines megakaryocyte migration on type I collagen.
, 2011 Background. The mechanisms that regulate the megakaryocyte (MK) development within the bone marrow environment remain poorly understood. The underlying relationships between MK maturation and bone marrow components are key factors in this process.
Alessandra Balduini +2 more
core