Results 71 to 80 of about 10,677,334 (330)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DSD-PAGE of type I and type III collagen.

, 2021
A: lane 1 –human collagen type III, lane 2 = molecular marker (Sigma). B: lane 1 = rat tail tendon collagen type I, lane 2 = molecular marker (Sigma). Gels were stained with coomassie blue. (PDF)
Michele Kirchner (11362062), Haiteng Deng (138991), Yujia Xu (2399122)   +2 more
core   +1 more source

Collagenofibrotic Glomerulopathy with Thrombotic Microangiopathy: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research
Collagenofibrotic Glomerulopathy (CG) is a very rare glomerular disease characterised by the massive accumulation of atypical type III collagen fibrils within the mesangial matrix and subendothelial space, as well as a marked increase in serum type III ...
Khushbu Agarwal, Kamal Kanodia, Shreya Solanki, Rashmi Patel, Kamlesh Suthar   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Specific cleavage of human type III collagen by human polymorphonuclear leukocyte elastase.

Journal of Biological Chemistry, 1980
Purified polymorphonuclear leukocyte elastase degraded native human liver type III collagen at 27 degrees C by making a cleavage through the triple helix. The enzyme had no effect on human type I collagen.
Carlo L. Mainardi, D. L. Hasty, J. Seyer, Andrew H. Kang   +3 more
semanticscholar   +1 more source

Lack of autoantibodies against collagen and related proteins in collagenous colitis

BMC Immunology, 2022
Introduction Collagenous colitis (CC) is a common cause of chronic diarrhea and is characterized by a subepithelial thickened collagen layer in the colonic mucosa.
Larsson JK, Roth B, Ohlsson B, Sjöberg K   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Glomerular localization of type III collagen in human kidney disease [PDF]

, 1989
Glomerular localization of type III collagen in human kidney disease. Kidney specimens taken from normal humans and patients with various renal diseases were examined by immunofluorescent and immunoelectron microscopy using a monoclonal antibody to the α,
Yoshioka, Kazuo, Takemura, Tsukasa, Akano, Norihisa, Miyamoto, Hiroyuki, Tohda, Machi, Ooshima, Akira, Maki, Sunao   +6 more
core   +1 more source

Type III collagen can be present on banded collagen fibrils regardless of fibril diameter

Journal of Cell Biology, 1987
Monoclonal antibodies that recognize an epitope within the triple helix of type III collagen have been used to examine the distribution of that collagen type in human skin, cornea, amnion, aorta, and tendon.
D. Keene, L. Sakai, H. Bachinger, R. Burgeson   +3 more
semanticscholar   +1 more source