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Bacteria-Killing Type IV Secretion Systems [PDF]
Frontiers in Microbiology, 2019 Bacteria have been constantly competing for nutrients and space for billions of years. During this time, they have evolved many different molecular mechanisms by which to secrete proteinaceous effectors in order to manipulate and often kill rival ...
Germán G. Sgro +10 more
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Named entity recognition for bacterial Type IV secretion systems. [PDF]
PLoS ONE, 2011 Research on specialized biological systems is often hampered by a lack of consistent terminology, especially across species. In bacterial Type IV secretion systems genes within one set of orthologs may have over a dozen different names.
Sophia Ananiadou +9 more
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Bactericidal type IV secretion system homeostasis in Xanthomonas citri.
PLoS Pathogens, 2020 Several Xanthomonas species have a type IV secretion system (T4SS) that injects a cocktail of antibacterial proteins into neighbouring Gram-negative bacteria, often leading to rapid lysis upon cell contact.
William Cenens +5 more
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AtlasT4SS: A curated database for type IV secretion systems [PDF]
BMC Microbiology, 2012 Background The type IV secretion system (T4SS) can be classified as a large family of macromolecule transporter systems, divided into three recognized sub-families, according to the well-known functions.
Souza Rangel C +7 more
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Structure of a type IV secretion system [PDF]
Nature, 2014 Bacterial type IV secretion systems translocate virulence factors into eukaryotic cells, distribute genetic material between bacteria and have shown potential as a tool for the genetic modification of human cells. Given the complex choreography of the substrate through the secretion apparatus, the molecular mechanism of the type IV secretion system has
Low, Harry +10 more
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Coxiella type IV secretion and cellular microbiology [PDF]
Current Opinion in Microbiology, 2009 Coxiella burnetii is a widespread zoonotic bacterial pathogen that causes human Q fever. In vivo, Coxiella displays a tropism for mononuclear phagocytes where it participates in biogenesis of a lysosome-like replication compartment to conduct its obligate intracellular lifestyle.
Daniel E, Voth, Robert A, Heinzen
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The versatile bacterial type IV secretion systems [PDF]
Nature Reviews Microbiology, 2003 Bacteria use type IV secretion systems for two fundamental objectives related to pathogenesis--genetic exchange and the delivery of effector molecules to eukaryotic target cells. Whereas gene acquisition is an important adaptive mechanism that enables pathogens to cope with a changing environment during invasion of the host, interactions between ...
Cascales, E., Christie, Peter
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The expanding bacterial type IV secretion lexicon [PDF]
Research in Microbiology, 2013 The bacterial type IV secretion systems (T4SSs) comprise a biologically diverse group of translocation systems functioning to deliver DNA or protein substrates from donor to target cells generally by a mechanism dependent on establishment of direct cell-to-cell contact.
Minny, Bhatty +2 more
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Evolution of Conjugation and Type IV Secretion Systems [PDF]
Molecular Biology and Evolution, 2012 Genetic exchange by conjugation is responsible for the spread of resistance, virulence, and social traits among prokaryotes. Recent works unraveled the functioning of the underlying type IV secretion systems (T4SS) and its distribution and recruitment for other biological processes (exaptation), notably pathogenesis.
Guglielmini, Julien +2 more
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Structure of a bacterial type IV secretion core complex at subnanometre resolution [PDF]
, 2013 Type IV secretion (T4S) systems are able to transport DNAs and/or proteins through the membranes of bacteria. They form large multiprotein complexes consisting of 12 proteins termed VirB1-11 and VirD4.
Chandran, Vidya +10 more
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