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Brucellosis and Type Iv Secretion
Future Microbiology, 2011Brucellosis is a global disease of domestic and wild mammals that is caused by intracellular bacteria of the genus Brucella. Although humans are not a natural reservoir for Brucella, infection in the human population is common in many countries, and brucellosis is one of the most common zoonotic infections.
Maarten F, de Jong, Renee M, Tsolis
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Type IV secretion and Brucella virulence
Veterinary Microbiology, 2002The type IV secretion system, encoded by the virB region, is a key virulence factor for Brucella. The 12 genes of the region form an operon that is specifically induced by phagosome acidification in cells after phagocytosis. We speculate that the system serves to secrete unknown effector molecules, which allow Brucella to pervert the host cell ...
Maria Laura, Boschiroli +10 more
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2014
This chapter provides an overview of the pathogenic involvement of Type IV secretion systems (T4SS), with a focus on the structural aspects and the molecular mechanisms of the type IV secretion process. The assembled knowledge gained from studies of individual secretion systems is used to propose a unified view of the architecture of the type IV ...
Schröder, G. +3 more
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This chapter provides an overview of the pathogenic involvement of Type IV secretion systems (T4SS), with a focus on the structural aspects and the molecular mechanisms of the type IV secretion process. The assembled knowledge gained from studies of individual secretion systems is used to propose a unified view of the architecture of the type IV ...
Schröder, G. +3 more
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Biochemistry of type IV secretion
Current Opinion in Microbiology, 1999In the past year, our knowledge of type IV transporters of Gram-negative bacteria has further expanded. Advances include the discovery of additional members of this family of proteins, increased knowledge of the morphologies of type IV transporters, and a better understanding of the mechanisms by which macromolecules are exported by these systems.
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Putative type IV secretion genes in Bacillus anthracis
Trends in Microbiology, 2007Although the physiology of Bacillus anthracis, the causative agent of anthrax, has been studied extensively, we still do not know how toxins are dispatched from the bacterial cell. Here, by means of distant homology and genome context analyses, we identify genes encoding putative type IV secretion system-related elements on the B.
Marcin, Grynberg +3 more
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Structural Biology of Bacterial Type IV Secretion Systems
Annual Review of Biochemistry, 2015Type IV secretion systems (T4SSs) are large multisubunit translocons, found in both gram-negative and gram-positive bacteria and in some archaea. These systems transport a diverse array of substrates from DNA and protein–DNA complexes to proteins, and play fundamental roles in both bacterial pathogenesis and bacterial adaptation to the cellular milieu
Vidya, Chandran Darbari +1 more
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Virulence-associated type IV secretion systems of Bartonella
Trends in Microbiology, 2005Type IV secretion systems (T4SSs) are transport machineries of Gram-negative bacteria that mediate interbacterial DNA-transfer, and secretion of virulence factors into eukaryotic target cells. A growing number of human pathogenic bacteria use T4SSs for intercellular delivery of effector molecules that modify host cellular functions in favour of the ...
Schroder, G., Dehio, C.
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Molecular architecture of bacterial type IV secretion systems
Trends in Biochemical Sciences, 2010In Gram-negative bacteria, type IV secretion (T4S) systems form ATP-powered complexes that span the entire cellular envelope and secrete a wide variety of substrates from single proteins to protein-protein and protein-DNA complexes. Recent structural data, namely the electron microscopy structure of the T4S core complex and the atomic-resolution ...
Gabriel, Waksman, Rémi, Fronzes
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DNA Transport through the Dynamic Type IV Secretion System
Infection and Immunity, 2023The versatile type IV secretion system (T4SS) nanomachine plays a pivotal role in bacterial pathogenesis and the propagation of antibiotic resistance determinants throughout microbial populations. In addition to paradigmatic DNA conjugation machineries, diverse T4SSs enable the delivery of multifarious effector proteins to target prokaryotic and ...
Mackenzie E. Ryan +2 more
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2014
Type IV transporters differ from other transporter systems in that type IV systems are used not only to transport proteins but also to mobilize DNA. In fact, it is likely that type IV transporters first evolved as conjugation systems that functioned to transfer genetic information between bacteria and only later were these systems modified by ...
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Type IV transporters differ from other transporter systems in that type IV systems are used not only to transport proteins but also to mobilize DNA. In fact, it is likely that type IV transporters first evolved as conjugation systems that functioned to transfer genetic information between bacteria and only later were these systems modified by ...
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