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Type II Secretion and Type IV Pili of Francisella
Annals of the New York Academy of Sciences, 2007Abstract: Francisella tularensis genomes encode homologues of type IV pili. Though several F. tularensis genes required for Tfp expression are homologous to genes required for type II secretion (T2S), these gene clusters mainly bear structural signatures that are typical of Tfp. There is preliminary evidence that different F.
Ake, Forsberg, Tina, Guina
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Regulation of Bacterial Type IV Secretion
2016This chapter explores the question of how bacterial pathogens regulate the biogenesis and function of their type IV secretion systems (T4SSs) in pathogenic settings. First, it describes a regulatory cascade involving the perception of multiple signals exchanged between Agrobacterium tumefaciens and its plant host. This signaling dialogue leads not only
Jenny A. Laverde-Gomez +2 more
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Architecture of the Type II Secretion and Type IV Pilus Machineries
Future Microbiology, 2010Motility and protein secretion are key processes contributing to bacterial virulence. A wealth of phylogenetic, biochemical and structural evidence support the hypothesis that the widely distributed type IV pilus (T4P) system, involved in twitching motility, and the type II secretion (T2S) system, involved in exoprotein release, are descended from a ...
Melissa, Ayers +2 more
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A Hitchhiker's Guide to Type IV Secretion
Science, 2004The Type IV secretion (T4S) apparatus of bacteria enables these organisms to exchange genetic material with each other, and to transmit DNA or effector proteins directly into host cells. The Perspective by Lybarger and Sandkvist discusses a new study (Cascales and Christie) that provides a remarkably detailed step-by-step analysis of how the ...
Suzanne R. Lybarger, Maria Sandkvist
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Type IV pili‐mediated secretion modulates Francisella virulence
Molecular Microbiology, 2006Summary Francisella tularensis are the causative agent of the zoonotic disease, tularaemia. Among four F. tularensis subspecies, ssp. novicida (F. novicida) is pathogenic only for immunocompromised individuals, while all four subspecies are pathogenic for mice. This study utilized proteomic and bioinformatic approaches to identify seven F.
Anthony J, Hager +8 more
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Type IV secretion machinery: molecular architecture and function
Biochemical Society Transactions, 2013Bacteria have evolved several secretion machineries to bring about transport of various virulence factors, nutrients, nucleic acids and cell-surface appendages that are essential for their pathogenesis. T4S (Type IV secretion) systems are versatile secretion systems found in various Gram-negative and Gram-positive bacteria and in few archaea.
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Health insurance status and cancer stage at diagnosis and survival in the United States
Ca-A Cancer Journal for Clinicians, 2022Jingxuan Zhao +2 more
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An overview of real‐world data sources for oncology and considerations for research
Ca-A Cancer Journal for Clinicians, 2022Lynne Penberthy +2 more
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An overview of precision oncology basket and umbrella trials for clinicians
Ca-A Cancer Journal for Clinicians, 2020Kristian Thorlund, Edward J Mills
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