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Structural organisation of the type IV secretion systems [PDF]
Current Opinion in Microbiology, 2014 Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNAs and/or proteins through the membranes of bacteria. Because of their complexity and multi-protein organisation, T4S systems have been extremely challenging to study structurally.
Waksman, Gabriel, Orlova, Elena V
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Genetics and Molecular Biology, 2005 The secretion of bacterial virulence factors and flagellar components requires the assistance of specific type III and flagellar chaperones. Standard computational annotation of the genome of Xanthomonas axonopodis pv citri, a plant pathogen that causes ...
Letícia Khater +5 more
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Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. [PDF]
, 2017 BACKGROUND: Central nervous system tuberculosis (CNS-TB) may be fatal even with treatment. Neutrophils are the key mediators of TB immunopathology, and raised CSF matrix metalloproteinase-9 (MMP-9) which correlates to neutrophil count in CNS-TB is ...
Brilha, S +6 more
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A genome-wide study of recombination rate variation in
BMC Evolutionary Biology, 2012 Background Rates of recombination vary by three orders of magnitude in bacteria but the reasons for this variation is unclear. We performed a genome-wide study of recombination rate variation among genes in the intracellular bacterium Bartonella henselae,
Guy Lionel +5 more
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High-Level Expression of Various Apolipoprotein (a) Isoforms by "Transferrinfection". The Role of Kringle IV Sequences in the Extracellular Association with Low-Density Lipoprotein [PDF]
, 1994 Characterization of the assembly of lipoprotein(a) [Lp(a)] is of fundamental importance to understanding the biosynthesis and metabolism of this atherogenic lipoprotein. Since no established cell lines exist that express Lp(a) or apolipoprotein(a) [apo(a)
Azrolan N. +45 more
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Disarming Bacterial Type IV Secretion
Chemistry & Biology, 2012 With common bacterial pathogens becoming increasingly resistant to the current therapeutic arsenal, there is a growing need to utilize alternative strategies when developing new antibacterial drugs. In this issue of Chemistry & Biology, Smith et al.
Cameron, Todd A. +1 more
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Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems [PDF]
, 2013 Relaxases are proteins responsible for the transfer of plasmid and chromosomal DNA from one bacterium to another during conjugation. They covalently react with a specific phosphodiester bond within DNA origin of transfer sequences, forming a nucleo ...
Gruber, C.J. +7 more
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Bacterial killing via a type IV secretion system [PDF]
Nature Communications, 2015 Type IV secretion systems (T4SSs) are multiprotein complexes that transport effector proteins and protein-DNA complexes through bacterial membranes to the extracellular milieu or directly into the cytoplasm of other cells. Many bacteria of the family Xanthomonadaceae, which occupy diverse environmental niches, carry a T4SS with unknown function but ...
Diorge P, Souza +11 more
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Biochemistry and Biophysics Reports, 2019 Mucin 5AC (MUC5AC) hypersecretion induces airway narrowing in patients with asthma, which leads to breathing problems. We investigated the regulation of MUC5AC secretion by extracellular matrix (ECM) proteins in human primary airway epithelial cells from
Yuho Ito, Jun Iwashita, Jun Murata
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Electron Cryotomography of Bacterial Secretion Systems [PDF]
, 2019 In biology, function arises from form. For bacterial secretion systems, which often span two membranes, avidly bind to the cell wall, and contain hundreds of individual proteins, studying form is a daunting task, made possible by electron cryotomography (
Abendroth +72 more
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