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Bacterial Type IV Secretion Systems: Versatile Virulence Machines [PDF]
Future Microbiology, 2012 Many bacterial pathogens employ multicomponent protein complexes to deliver macromolecules directly into their eukaryotic host cell to promote infection. Some Gram-negative pathogens use a versatile Type IV secretion system (T4SS) that can translocate DNA or proteins into host cells.
Daniel E, Voth +2 more
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The Helicobacter pylori Cag Type IV Secretion System
Trends in Microbiology, 2020 Colonization of the human stomach with Helicobacter pylori strains containing the cag pathogenicity island is a risk factor for development of gastric cancer. The cag pathogenicity island contains genes encoding a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS). The molecular architecture of the H.
Timothy L, Cover +2 more
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Frontiers in Microbiology, 2021 Cell membranes are not homogenous but compartmentalized into lateral microdomains, which are considered as biochemical reaction centers for various physiological processes in eukaryotes and prokaryotes. Due to their special lipid and protein composition,
Simon Czolkoss +5 more
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The structural biology of type IV secretion systems [PDF]
Nature Reviews Microbiology, 2009 Type IV secretion systems (T4SSs) are versatile secretion systems that are found in both Gram-negative and Gram-positive bacteria and secrete a wide range of substrates, from single proteins to protein-protein and protein-DNA complexes. They usually consist of 12 components that are organized into ATP-powered, double-membrane-spanning complexes.
Rémi, Fronzes +2 more
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Coupling Proteins in Type IV Secretion
, 2017 Type IV coupling proteins (T4CPs) are essential constituents of most type IV secretion systems (T4SSs), and probably the most intriguing component in terms of their evolutionary origin and functional role. Coupling proteins have coevolved with their cognate secretion system and translocated substrates.
Llosa, Matxalen, Alkorta, Itziar
openaire +3 more sources
Frontiers in Cellular and Infection Microbiology, 2023 Infections caused by Gram-negative pathogens pose a major health burden. Both respiratory and gastrointestinal infections are commonly associated with these pathogens.
Nadja Blasey +3 more
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Biological Diversity of Prokaryotic Type IV Secretion Systems [PDF]
Microbiology and Molecular Biology Reviews, 2009 SUMMARYType IV secretion systems (T4SS) translocate DNA and protein substrates across prokaryotic cell envelopes generally by a mechanism requiring direct contact with a target cell. Three types of T4SS have been described: (i) conjugation systems, operationally defined as machines that translocate DNA substrates intercellularly by a contact-dependent ...
Alvarez-Martinez, Cristina E +1 more
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Divergence of Legionella Effectors Reversing Conventional and Unconventional Ubiquitination
Frontiers in Cellular and Infection Microbiology, 2020 The intracellular bacterial pathogen Legionella pneumophila employs bacteria-derived effector proteins in a variety of functions to exploit host cellular systems.
Tomoe Kitao +4 more
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Identification of Anaplasma marginale type IV secretion system effector proteins. [PDF]
PLoS ONE, 2011 Anaplasma marginale, an obligate intracellular alphaproteobacterium in the order Rickettsiales, is a tick-borne pathogen and the leading cause of anaplasmosis in cattle worldwide. Complete genome sequencing of A.
Svetlana Lockwood +6 more
doaj +1 more source
Polar delivery of Legionella type IV secretion system substrates is essential for virulence [PDF]
, 2017 A recurrent emerging theme is the targeting of proteins to subcellular microdomains within bacterial cells, particularly to the poles. In most cases, it has been assumed that this localization is critical to the protein’s function. Legionella pneumophila
Chang, Yi-Wei +4 more
core +1 more source