Cryo-EM structure of a type IV secretion system. [PDF]
Nature, 2022 Bacterial conjugation is the fundamental process of unidirectional transfer of DNAs, often plasmid DNAs, from a donor cell to a recipient cell1. It is the primary means by which antibiotic resistance genes spread among bacterial populations2,3.
Macé K +12 more
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DNA Transport through the Dynamic Type IV Secretion System. [PDF]
Infect Immun, 2023 The versatile type IV secretion system (T4SS) nanomachine plays a pivotal role in bacterial pathogenesis and the propagation of antibiotic resistance determinants throughout microbial populations.
Ryan ME, Damke PP, Shaffer CL.
europepmc +4 more sources
In Vivo Structures of the Helicobacter pylori cag Type IV Secretion System [PDF]
Cell Reports, 2018 Summary: The type IV secretion system (T4SS) is a versatile nanomachine that translocates diverse effector molecules between microbes and into eukaryotic cells. Here, using electron cryotomography, we reveal the molecular architecture of the Helicobacter
Yi-Wei Chang +4 more
doaj +7 more sources
The Helicobacter pylori Cag Type IV Secretion System. [PDF]
Trends Microbiol, 2020 Colonization of the human stomach with Helicobacter pylori strains containing the cag pathogenicity island is a risk factor for development of gastric cancer.
Cover TL, Lacy DB, Ohi MD.
europepmc +5 more sources
Structure of the Helicobacter pylori Cag type IV secretion system [PDF]
eLife, 2019 Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells.
Jeong Min Chung +7 more
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Functional plasticity in the type IV secretion system of Helicobacter pylori. [PDF]
PLoS Pathogens, 2013 Helicobacter pylori causes clinical disease primarily in those individuals infected with a strain that carries the cytotoxin associated gene pathogenicity island (cagPAI).
Roberto M Barrozo +10 more
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Structure of a type IV secretion system core complex encoded by multi-drug resistance F plasmids. [PDF]
Nat Commun, 2022 Bacterial type IV secretion systems (T4SSs) are largely responsible for the proliferation of multi-drug resistance. We solved the structure of the outer-membrane core complex (OMCC F ) of a T4SS encoded by a conjugative F plasmid at
Liu X +4 more
europepmc +2 more sources
Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex
eLife, 2020 Legionella pneumophila is an opportunistic pathogen that causes the potentially fatal pneumonia Legionnaires’ Disease. This infection and subsequent pathology require the Dot/Icm Type IV Secretion System (T4SS) to deliver effector proteins into host ...
Clarissa L Durie +8 more
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Bacterial type IV secretion system induces specific and nonspecific protective immunity [PDF]
mBioPathogenic microbes trigger rapid and robust innate immune responses that effectively restrict pathogen replication and promote long-lasting adaptive immunity.
Fernanda V. S. Castanheira +7 more
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Species-specific components of the Helicobacter pylori Cag type IV secretion system [PDF]
Infection and ImmunityHelicobacter pylori strains containing the cag pathogenicity island (PAI) deliver an effector protein (CagA) and non-protein substrates into gastric cells through a process that requires the Cag type IV secretion system (T4SS).
Kaeli N. Bryant +8 more
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