Results 121 to 130 of about 490,629 (332)

T4Seeker: a hybrid model for type IV secretion effectors identification

BMC Biology
Background The type IV secretion system is widely present in various bacteria, such as Salmonella, Escherichia coli, and Helicobacter pylori. These bacteria use the type IV secretion system to secrete type IV secretion effectors, infect host cells, and ...
Jing Li, Shida He, Jian Zhang, Feng Zhang, Quan Zou, Fengming Ni   +5 more
doaj   +1 more source

Identification of protein secretion systems and novel secreted proteins in Rhizobium leguminosarum bv. viciae

BMC Genomics, 2008
Background Proteins secreted by bacteria play an important role in infection of eukaryotic hosts. Rhizobia infect the roots of leguminous plants and establish a mutually beneficial symbiosis.
Krehenbrink Martin, Downie J Allan
doaj   +1 more source

The VirE2 protein of Agrobacterium tumefaciens: the Yin and Yang of T-DNA transfer [PDF]

, 2017
Agrobacterium tumefaciens has evolved a unique mechanism to solve the problem of transferring DNA across five bilayers; the inner and outer membranes of the bacterium, the plasma membrane of the plant cell and the double membrane formed by the nuclear ...
Duckely, Myriam, Hohn, Barbara
core  

BIOGENESIS, ARCHITECTURE, AND FUNCTION OF BACTERIAL TYPE IV SECRETION SYSTEMS [PDF]

Annual Review of Microbiology, 2005
Type IV secretion (T4S) systems are ancestrally related to bacterial conjugation machines. These systems assemble as a translocation channel, and often also as a surface filament or protein adhesin, at the envelopes of Gram-negative and Gram-positive bacteria.
Christie, Peter, Atmakuri, Krishnamohan, Krishnamoorthy, Vidhya, Jakubowski, Simon, Cascales, E.   +4 more
openaire   +3 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Type IV Secretion System Is Not Involved in Infection Process in Citrus

International Journal of Microbiology, 2014
The type IV secretion system (T4SS) is used by Gram-negative bacteria to translocate protein and DNA substrates across the cell envelope and into target cells. Xanthomonas citri subsp.
Tiago Rinaldi Jacob, Marcelo Luiz de Laia, Leandro Marcio Moreira, Janaína Fernandes Gonçalves, Flavia Maria de Souza Carvalho, Maria Inês Tiraboschi Ferro, Jesus Aparecido Ferro   +6 more
doaj   +1 more source

Conjugative type IV secretion systems in Gram-positive bacteria

Plasmid, 2013
Bacterial conjugation presents the most important means to spread antibiotic resistance and virulence factors among closely and distantly related bacteria. Conjugative plasmids are the mobile genetic elements mainly responsible for this task. All the genetic information required for the horizontal transmission is encoded on the conjugative plasmids ...
Goessweiner-Mohr, Nikolaus, Arends, Karsten, Keller, Walter, Grohmann, Elisabeth   +3 more
openaire   +4 more sources

Phylogenomics Reveals a DiverseRickettsialesType IV Secretion System [PDF]

Infection and Immunity, 2010
ABSTRACTWith an obligate intracellular lifestyle,Alphaproteobacteriaof the orderRickettsialeshave inextricably coevolved with their various eukaryotic hosts, resulting in small, reductive genomes and strict dependency on host resources. Unsurprisingly, large portions ofRickettsialesgenomes encode proteins involved in transport and secretion.
Gillespie, Joseph J, Brayton, Kelly A, Williams, Kelly P, Quevedo Diaz, Marco A, Brown, Wendy C, Azad, Abdu F, Sobral, Bruno W   +6 more
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source