Bactericidal type IV secretion system homeostasis in Xanthomonas citri. [PDF]
PLoS Pathogens, 2020 Several Xanthomonas species have a type IV secretion system (T4SS) that injects a cocktail of antibacterial proteins into neighbouring Gram-negative bacteria, often leading to rapid lysis upon cell contact.
William Cenens +5 more
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Bacteria-Killing Type IV Secretion Systems [PDF]
Frontiers in Microbiology, 2019 Bacteria have been constantly competing for nutrients and space for billions of years. During this time, they have evolved many different molecular mechanisms by which to secrete proteinaceous effectors in order to manipulate and often kill rival ...
Germán G. Sgro +10 more
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Bacterial killing via a type IV secretion system [PDF]
Nature Communications, 2015 Type IV secretion systems (T4SSs) are multiprotein complexes that transport effector proteins and protein–DNA complexes through bacterial membranes to the extracellular milieu or directly into the cytoplasm of other cells.
D. P. Souza +11 more
semanticscholar +3 more sources
In Situ Visualization of the pKM101-Encoded Type IV Secretion System Reveals a Highly Symmetric ATPase Energy Center. [PDF]
mBio, 2021 Bacterial type IV secretion systems (T4SSs) play central roles in antibiotic resistance spread and virulence. By cryo-electron tomography (CryoET), we solved the structure of the plasmid pKM101-encoded T4SS in the native context of the bacterial cell ...
Khara P, Song L, Christie PJ, Hu B.
europepmc +2 more sources
Structural basis for effector recognition by an antibacterial type IV secretion system. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Type IV secretion systems (T4SSs) have been studied for more than 70 y because of their roles in mediating horizontal DNA transfer, responsible for the spread of antibiotic resistance, and the injection of virulence factors into animal and ...
Oka GU +10 more
europepmc +2 more sources
Recent advances in structural studies of the Legionella pneumophila Dot/Icm type IV secretion system. [PDF]
Microbiol Immunol, 2022 The intracellular bacterial pathogen Legionella pneumophila utilizes the Dot/Icm type IV secretion system to translocate approximately 300 effector proteins to establish a replicative niche known as the Legionella‐containing vacuole.
Kitao T, Kubori T, Nagai H.
europepmc +2 more sources
Translocation through the conjugative Type 4 secretion system requires unfolding of its protein substrate [PDF]
Journal of Bacteriology, 2018 Bacterial conjugation, a mechanism of horizontal gene transfer, is the major means by which antibiotic resistance spreads among bacteria (1, 2). Conjugative plasmids are transferred from one bacterium to another through a type IV secretion system (T4SS ...
Trokter, Martina, Waksman, Gabriel
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Type IV Secretion System of Brucella spp. and its Effectors [PDF]
Frontiers in Cellular and Infection Microbiology, 2015 Brucella spp. cause brucellosis in domestic and wild animals. They are intracellular bacterial pathogens and used as model organisms to study intracellular bacterial infections.
Yuehua eKe +3 more
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Coxiella burnetii infects osteoclasts and alters their differentiation and function in a type IV secretion system-dependent manner [PDF]
Frontiers in ImmunologyChronic Q fever is caused by persistent infection with the Gram-negative bacterium Coxiella burnetii. The mechanisms underlying this persistence remain elusive, but the presence of the bacteria in the bone marrow of C. burnetii-infected patients has been
Chaobo Lai +18 more
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Type IV secretion systems: from structures to mechanisms
The EMBO JournalBacterial conjugation is the fundamental process of unidirectional transfer of DNA from a “donor” cell to a “recipient” cell. It is the primary means by which antibiotic resistance genes spread among bacterial populations.
Pierre Paillard +3 more
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