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Structure of a type IV secretion system [PDF]
Nature, 2014 Bacterial type IV secretion systems translocate virulence factors into eukaryotic cells, distribute genetic material between bacteria and have shown potential as a tool for the genetic modification of human cells. Given the complex choreography of the substrate through the secretion apparatus, the molecular mechanism of the type IV secretion system has
H. H. Low +10 more
semanticscholar +3 more sources
The Missing Pieces: The Role of Secretion Systems in Campylobacter jejuni Virulence
Biomolecules, 2023 Campylobacter jejuni is likely the most common bacterial cause of gastroenteritis worldwide, responsible for millions of cases of inflammatory diarrhea characterized by severe abdominal cramps and blood in the stool. Further, C.
Amber D. Gabbert +7 more
doaj +1 more source
The Legionella pneumophila Dot/Icm type IV secretion system and its effectors.
Microbiology, 2022 To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein secretion systems to release virulence factors at the host–pathogen interface and/or deliver them directly into host cells. An outstanding example of the complexity
Daniel C Lockwood +3 more
semanticscholar +1 more source
Presence and analysis of plasmids in human and animal associated Arcobacter species [PDF]
, 2014 In this study, we report the screening of four Arcobacter species for the presence of small and large plasmids. Plasmids were present in 9.9% of the 273 examined strains.
De Zutter, Lieven +7 more
core +12 more sources
Nature Communications, 2021 Adherent-invasive Escherichia coli (AIEC) are pathogenic bacteria frequently isolated from patients who have Crohn’s disease (CD). Despite the phenotypic differences between AIEC and commensal E.
W. Elhenawy +7 more
semanticscholar +1 more source
The versatile bacterial type IV secretion systems [PDF]
Nature Reviews Microbiology, 2003 Bacteria use type IV secretion systems for two fundamental objectives related to pathogenesis--genetic exchange and the delivery of effector molecules to eukaryotic target cells. Whereas gene acquisition is an important adaptive mechanism that enables pathogens to cope with a changing environment during invasion of the host, interactions between ...
Cascales, E., Christie, Peter
openaire +3 more sources
Molecular architecture of bacterial type IV secretion systems
PLOS Pathogens, 2022 Bacterial type IV secretion systems (T4SSs) are a versatile group of nanomachines that can horizontally transfer DNA through conjugation and deliver effector proteins into a wide range of target cells. The components of T4SSs in gram-negative bacteria are organized into several large subassemblies: an inner membrane complex, an outer membrane core ...
Michael J. Sheedlo +3 more
openaire +3 more sources
Evolution of Conjugation and Type IV Secretion Systems [PDF]
Molecular Biology and Evolution, 2012 Genetic exchange by conjugation is responsible for the spread of resistance, virulence, and social traits among prokaryotes. Recent works unraveled the functioning of the underlying type IV secretion systems (T4SS) and its distribution and recruitment for other biological processes (exaptation), notably pathogenesis.
Guglielmini, Julien +2 more
openaire +5 more sources
Structural organisation of the type IV secretion systems [PDF]
Current Opinion in Microbiology, 2014 Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNAs and/or proteins through the membranes of bacteria. Because of their complexity and multi-protein organisation, T4S systems have been extremely challenging to study structurally.
Waksman, Gabriel, Orlova, Elena V
openaire +2 more sources
Identification of Anaplasma marginale type IV secretion system effector proteins. [PDF]
PLoS ONE, 2011 Anaplasma marginale, an obligate intracellular alphaproteobacterium in the order Rickettsiales, is a tick-borne pathogen and the leading cause of anaplasmosis in cattle worldwide. Complete genome sequencing of A.
Svetlana Lockwood +6 more
doaj +1 more source