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Structural Biology of Bacterial Type IV Secretion Systems
Annual Review of Biochemistry, 2015Type IV secretion systems (T4SSs) are large multisubunit translocons, found in both gram-negative and gram-positive bacteria and in some archaea. These systems transport a diverse array of substrates from DNA and protein–DNA complexes to proteins, and play fundamental roles in both bacterial pathogenesis and bacterial adaptation to the cellular milieu
Vidya, Chandran Darbari +1 more
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Virulence-associated type IV secretion systems of Bartonella
Trends in Microbiology, 2005Type IV secretion systems (T4SSs) are transport machineries of Gram-negative bacteria that mediate interbacterial DNA-transfer, and secretion of virulence factors into eukaryotic target cells. A growing number of human pathogenic bacteria use T4SSs for intercellular delivery of effector molecules that modify host cellular functions in favour of the ...
Schroder, G., Dehio, C.
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Molecular architecture of bacterial type IV secretion systems
Trends in Biochemical Sciences, 2010In Gram-negative bacteria, type IV secretion (T4S) systems form ATP-powered complexes that span the entire cellular envelope and secrete a wide variety of substrates from single proteins to protein-protein and protein-DNA complexes. Recent structural data, namely the electron microscopy structure of the T4S core complex and the atomic-resolution ...
Gabriel, Waksman, Rémi, Fronzes
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2014
Type IV transporters differ from other transporter systems in that type IV systems are used not only to transport proteins but also to mobilize DNA. In fact, it is likely that type IV transporters first evolved as conjugation systems that functioned to transfer genetic information between bacteria and only later were these systems modified by ...
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Type IV transporters differ from other transporter systems in that type IV systems are used not only to transport proteins but also to mobilize DNA. In fact, it is likely that type IV transporters first evolved as conjugation systems that functioned to transfer genetic information between bacteria and only later were these systems modified by ...
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The Type IV Secretion System in Helicobacter Pylori
Future Microbiology, 2018Helicobacter pylori (H. pylori) has an essential role in the pathogenesis of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. The severity of the host inflammatory responses against the bacteria have been straightly associated with a special bacterial virulence factor, the cag pathogenicity island, which ...
Xiao-Yan, Yuan +2 more
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Type IV secretion systems and their effectors in bacterial pathogenesis
Current Opinion in Microbiology, 2006Type IV secretion systems (T4SSs) are membrane-associated transporter complexes used by various bacteria to deliver substrate molecules to a wide range of target cells. T4SSs are involved in horizontal DNA transfer to other bacteria and eukaryotic cells, in DNA uptake from or release into the extracellular milieu, in toxin secretion and in the ...
Backert, S., Meyer, T.
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Conservation of the Type IV Secretion System throughout Wolbachia evolution
Biochemical and Biophysical Research Communications, 2009The Type IV Secretion System (T4SS) is an efficient pathway with which bacteria can mediate the transfer of DNA and/or proteins to eukaryotic cells. In Wolbachia pipientis, a maternally inherited obligate endosymbiont of arthropods and nematodes, two operons of vir genes, virB3-B6 and virB8-D4, encoding a T4SS were previously identified and ...
Pichon, Samuel +5 more
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Exploring cargo transport mechanics in the type IV secretion systems
Trends in Microbiology, 2005Type IV secretion systems (T4SSs) are used by various bacteria to deliver protein and DNA molecules to a wide range of target cells. These include systems that are directly involved in pathogenesis, such as the secretion of pertussis toxin by Bordetella pertussis into human cells and the delivery of single-stranded DNA (ssDNA) into plants by ...
Jianxiong, Li +3 more
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Health insurance status and cancer stage at diagnosis and survival in the United States
Ca-A Cancer Journal for Clinicians, 2022Jingxuan Zhao +2 more
exaly
An overview of real‐world data sources for oncology and considerations for research
Ca-A Cancer Journal for Clinicians, 2022Lynne Penberthy +2 more
exaly