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Frontiers in Cellular and Infection Microbiology, 2020 Type IV secretion systems are protein secretion machineries that are frequently used by pathogenic bacteria to inject their virulence factors into target cells of their respective hosts.
Clara Lettl +16 more
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F factor conjugation is a true type IV secretion system. [PDF]
FEMS Microbiology Letters, 2003 The F sex factor of Escherichia coli is a paradigm for bacterial conjugation and its transfer (tra) region represents a subset of the type IV secretion system (T4SS) family. The F tra region encodes eight of the 10 highly conserved (core) gene products of T4SS including TraAF (pilin), the TraBF, -KF (secretin-like), -VF (lipoprotein) and TraCF (NTPase),
T. Lawley +3 more
semanticscholar +3 more sources
Bacterial type IV secretion systems in human disease [PDF]
Molecular Microbiology, 2009 SummaryType IV secretion (T4S) systems are versatile machines involved in many processes relevant to bacterial virulence, such as horizontal DNA transfer and effector translocation into human cells. A recent workshop organized by the International University of Andalousia in Baeza, Spain, covered most aspects of bacterial T4S relevant to human disease,
Llosa, M., Roy, C., Dehio, C.
openaire +3 more sources
Type-IVC secretion system: a novel subclass of type IV secretion system (T4SS) common existing in gram-positive genus Streptococcus. [PDF]
PLoS ONE, 2012 A growing number of pathogens are being found to possess specialized secretion systems which they use in various ways to subvert host defenses. Type IV secretion system (T4SS) is one of versatile secretion systems essential for the virulence and even ...
Wen Zhang +3 more
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Frontiers in Microbiology, 2021 Cell membranes are not homogenous but compartmentalized into lateral microdomains, which are considered as biochemical reaction centers for various physiological processes in eukaryotes and prokaryotes. Due to their special lipid and protein composition,
Simon Czolkoss +5 more
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mBio, 2021 Many bacteria carry plasmids and other mobile genetic elements (MGEs) whose conjugative transfer through encoded type IV secretion systems (T4SSs), or “mating channels,” can lead to a rapid intra- and interspecies proliferation of genes encoding ...
A. A. M. Al Mamun +2 more
semanticscholar +1 more source
Bacterial Type IV Secretion Systems: Versatile Virulence Machines [PDF]
Future Microbiology, 2012 Many bacterial pathogens employ multicomponent protein complexes to deliver macromolecules directly into their eukaryotic host cell to promote infection. Some Gram-negative pathogens use a versatile Type IV secretion system (T4SS) that can translocate DNA or proteins into host cells.
Daniel E, Voth +2 more
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The Mosaic Type IV Secretion Systems [PDF]
EcoSal Plus, 2016 Escherichia coli and other Gram-negative and -positive bacteria employ type IV secretion systems (T4SSs) to translocate DNA and protein substrates, generally by contact-dependent mechanisms, to other cells. The T4SSs functionally encompass two major subfamilies, the conjugation systems and the effector translocators.
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Frontiers in Molecular Biosciences, 2022 Conjugative transfer is the most important means for spreading antibiotic resistance genes. It is used by Gram-positive and Gram-negative bacteria, and archaea as well.
Tamara M.I. Berger +13 more
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Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. [PDF]
, 2017 BACKGROUND: Central nervous system tuberculosis (CNS-TB) may be fatal even with treatment. Neutrophils are the key mediators of TB immunopathology, and raised CSF matrix metalloproteinase-9 (MMP-9) which correlates to neutrophil count in CNS-TB is ...
Brilha, S +6 more
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