Results 41 to 50 of about 490,629 (332)

Biological Diversity of Prokaryotic Type IV Secretion Systems [PDF]

Microbiology and Molecular Biology Reviews, 2009
SUMMARYType IV secretion systems (T4SS) translocate DNA and protein substrates across prokaryotic cell envelopes generally by a mechanism requiring direct contact with a target cell. Three types of T4SS have been described: (i) conjugation systems, operationally defined as machines that translocate DNA substrates intercellularly by a contact-dependent ...
Alvarez-Martinez, Cristina E, Christie, Peter J   +1 more
openaire   +2 more sources

An anomalous type IV secretion system in Rickettsia is evolutionarily conserved. [PDF]

PLoS ONE, 2009
Bacterial type IV secretion systems (T4SSs) comprise a diverse transporter family functioning in conjugation, competence, and effector molecule (DNA and/or protein) translocation.
Joseph J Gillespie, Nicole C Ammerman, Sheila M Dreher-Lesnick, M Sayeedur Rahman, Micah J Worley, Joao C Setubal, Bruno S Sobral, Abdu F Azad   +7 more
doaj   +1 more source

The Trw type IV secretion system of Bartonella mediates host-specific adhesion to erythrocytes [PDF]

, 2010
Bacterial pathogens typically infect only a limited range of hosts; however, the genetic mechanisms governing host-specificity are poorly understood.
A Seubert, Antoine Danchin, B Nystedt, BB Chomel, BB Chomel, BB Finlay, C Dehio, C Dehio, C Dehio, C Dehio, C Foucault, Christoph Dehio, CM Alsmark, Craig R. Roy, D Bermond, D Posada, Danielle Le Rhun, DC Scherer, DF Welch, Evelyne Lenaour, Francis Biville, Geneviève Marignac, H Kabeya, HD de Paz, HD de Paz, Henri Jean Boulouis, Henri Saenz, HJ Boulouis, HL Saenz, HL Saenz, Hong Kuan Deng, Huanming Yang, JC Wilgenbusch, Jing Wang, JM Rolain, JM Rolain, JM Rolain, JR Mehock, K Yamamoto, Lionel Arnaud, M Dehio, M Lecuit, M Mavris, Maria Mavris, Maxime Quebatte, ME Kovach, Muriel Vayssier-Taussat, MY Kosoy, N Khelef, O Disson, PE Fournier, Philipp Engel, R Heller, R Heller, R Schulein, R Schulein, SA Coleman, Sandra Cescau, SJ Mitchell, Z Yang, Z Yang, Z Yang   +61 more
core   +5 more sources

Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila

Nature Communications, 2020
Legionella pneumophila is a bacterial pathogen that utilises a Type IV secretion (T4S) system to inject effector proteins into human macrophages. Essential to the recruitment and delivery of effectors to the T4S machinery is the membrane-embedded T4 ...
A. Meir, K. Macé, N. Lukoyanova, D. Chetrit, M. Hospenthal, Adam Redzej, C. Roy, G. Waksman   +7 more
semanticscholar   +1 more source

The structural biology of type IV secretion systems [PDF]

Nature Reviews Microbiology, 2009
Type IV secretion systems (T4SSs) are versatile secretion systems that are found in both Gram-negative and Gram-positive bacteria and secrete a wide range of substrates, from single proteins to protein-protein and protein-DNA complexes. They usually consist of 12 components that are organized into ATP-powered, double-membrane-spanning complexes.
Rémi, Fronzes, Peter J, Christie, Gabriel, Waksman   +2 more
openaire   +2 more sources

Secretion systems and signal exchange between nitrogen-fixing rhizobia and legumes

Frontiers in Plant Science, 2015
The formation of symbiotic nitrogen-fixing nodules on the roots and/or stem of leguminous plants involves a complex signal exchange between both partners. Since many microorganisms are present in the soil, legumes and rhizobia must recognize and initiate
Matthew S Nelson, Michael J Sadowsky
doaj   +1 more source

Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS

eLife, 2021
Legionella pneumophila is an opportunistic pathogen that causes the potentially fatal pneumonia known as Legionnaires’ disease. The pathology associated with infection depends on bacterial delivery of effector proteins into the host via the membrane ...
Michael J Sheedlo, Clarissa L Durie, Jeong Min Chung, Louise Chang, Jacquelyn Roberts, Michele Swanson, Dana Borden Lacy, Melanie D Ohi   +7 more
doaj   +1 more source

High-Level Expression of Various Apolipoprotein (a) Isoforms by "Transferrinfection". The Role of Kringle IV Sequences in the Extracellular Association with Low-Density Lipoprotein [PDF]

, 1994
Characterization of the assembly of lipoprotein(a) [Lp(a)] is of fundamental importance to understanding the biosynthesis and metabolism of this atherogenic lipoprotein. Since no established cell lines exist that express Lp(a) or apolipoprotein(a) [apo(a)
Azrolan N., Boerwinkle E., Brunner C., Chiesa G., Chung B. Y., Cotten M., Deutscher S. L., Deutscher S. L., Dieplinger H., Edelberg J. M., Green S., Griffiths G., Guevara J., Jr., Huby T., Ichinose A., Kamboh M. I., Koschinsky M. L., Koschinsky M. L., Koschinsky M. L., Kostner G. M., Kraft H- G., Kraft H. G., Krempler F., Krempler F., Lackner C., Linton M. F., Malgaretti N., McGregor G. R., McLean J. W., Menzel H. J., Phillips M. L., Rader D. J., Sambrook J., Sandholzer C., Scanu A. M., Selden R. F., Sommer A., Stanley P., Trieu V. N., Utermann G., Utermann G., Utermann G., Wagner E., White A. L., Zatloukal K., Zechner R„   +45 more
core   +1 more source

ALPK1 and TIFA dependent innate immune response triggered by the Helicobacter pylori type IV secretion system

bioRxiv, 2017
Activation of transcription factor NF-κB is a hallmark of infection with the gastric pathogen Helicobacter pylori and associated with inflammation and carcinogenesis. Genome-wide RNAi screening revealed numerous hits involved in H. pylori-, but not IL-1β-
S. Zimmermann, Lennart Pfannkuch, Munir A. Al‐Zeer, S. Bartfeld, M. Koch, Jianping Liu, C. Rechner, Meike Soerensen, O. Sokolova, A. Zamyatina, P. Kosma, A. Mäurer, Frithjof Glowinski, K. Pleissner, M. Schmid, V. Brinkmann, M. Naumann, Marion Rother, N. Machuy, T. Meyer   +19 more
semanticscholar   +1 more source

Named Entity Recognition for Bacterial Type IV Secretion Systems [PDF]

PLoS ONE, 2011
Research on specialized biological systems is often hampered by a lack of consistent terminology, especially across species. In bacterial Type IV secretion systems genes within one set of orthologs may have over a dozen different names. Classifying research publications based on biological processes, cellular components, molecular functions, and ...
Ananiadou, Sophia, Sullivan, Dan, Black, William, Levow, Gina Anne, Gillespie, Joseph J., Mao, Chunhong, Pyysalo, Sampo, Kolluru, BalaKrishna, Tsujii, Junichi, Sobral, Bruno   +9 more
openaire   +5 more sources