Results 131 to 140 of about 8,452,020 (344)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
'Barcode fishing' for archival DNA from historical type material overcomes taxonomic hurdles, enabling the description of a new frog species. [PDF]
Sci Rep, 2020 Scherz MD +10 more
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Soil Organisms, 2013 During preparation of ‘Capbryinae & Entomobryini’ (Jordana 2012) for the series Synopses on Palaearctic Collembola (Volume 7, Part 1), many specimens were studied from museums within and outside the study area.
Enrique Baquero +2 more
doaj
, 2011 Cross-linked polyethylene (XLPE) is commonly used within high voltage cable insulation. It has improved thermal and mechanical resistance compared to normal low density polyethylene (LDPE).
Dao, N L, Lewin, P L, Swingler, S G
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Cumene cracking on modified mesoporous material type MCM-41
Bulletin of the Chemical Society of Ethiopia, 2006 The effect of ionic exchange degree of aluminated mesoporous materials H(X)-AlMCM-41 materials, the method of its exchange mode and its grains form were investigated for the mesoporous catalytic activity in the cumene (i.e.
Ahmed Belhakem, Abdelkader Bengueddach
doaj
CuO nanorods grown vertically on graphene nanosheets as a battery-type material for high-performance supercapacitor electrodes. [PDF]
RSC Adv, 2020 Zhai M, Li A, Hu J.
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source