Results 251 to 260 of about 8,452,020 (344)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Effects of Gastric Acid and Antiacid Medications on Surface Roughness, Morphology, and Optical Properties of Resin-Based Materials. [PDF]

Polymers (Basel)
Tüter Bayraktar E, Şenol AA, Alkan E, Doğu Kaya B, Tağtekin D.   +4 more
europepmc   +1 more source

Analysis of the attractiveness of materials as applied to the fuel cycle of high-power fast reactor of Bn-type

, 2016
Evgeniya Mihajlovna L’vova, A. N. Chebeskov   +1 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

New records of semi-aquatic bugs (Hemiptera, Heteroptera, Gerromorpha) from the South Region of Brazil. [PDF]

Biodivers Data J
Floriano CF, Paiva NO, Cordeiro IDRS, Franco CL, Rodrigues JMDS, Moreira FFF.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Marginal Misfit Assessment in Common Restorative Materials for Cement-Retained Fixed Implant Prostheses: An In Vitro Comparative Study. [PDF]

Clin Exp Dent Res
Diaz P, Miegimolle B, Martin A, Mosaddad SA, Tobar C, Suarez MJ.   +5 more
europepmc   +1 more source

Pluck-pools as diagnostic samples for detecting porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 in porcine abortion material and stillbirths

Heinrich Kreutzmann, Christine Unterweger, Lukas Schwarz, Katharina Dimmel, Angelika Auer, Till Rümenapf, Andrea Ladinig   +6 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Development of detection sensitivity to material properties in school-age children. [PDF]

Sci Rep
Imura T, Sawayama M, Shirai N, Tomonaga M, Nishida S.   +4 more
europepmc   +1 more source