Results 131 to 140 of about 13,143,476 (301)
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
The HoTT Library: A Formalization of Homotopy Type Theory in Coq
, 2017 International audienceWe report on the development of the HoTT library, a formal- ization of homotopy type theory in the Coq proof assistant. It formalizes most of basic homotopy type theory, including univalence, higher inductive types, and significant ...
Peter LeFanu Lumsdaine +13 more
core +1 more source
CoRR, 2014 We present some first steps in the more general setting of the interpretation of dependent type theory in Ludics. The framework is the following: a (Martin-Lof) type A is represented by a behaviour (which corresponds to a formula) in such a way that canonical elements of A are interpreted in a set that is principal for the behaviour, where principal ...
openaire +2 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Transcending the Theory of Types
The intensional paradoxes present a continuing challenge to any theory of concepts (properties, attributes, propositional functions). In his seminal paper on Russell, Gödel expressed sympathy for the strategy of limited ranges of significance, which is derived from but logically independent of Russell’s theory of types.
Picenni, S., Schindler, T.
openaire +3 more sources
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Graded Modal Type Theory, Formalized [Elektronisk resurs]
A graded modal type theory equips a type theory with a semiring of grades, which enables encoding additional information of some kind. A typical application of such a system is to encode quantitative information, specifically how many times variables are
Eriksson, Oskar,
core
Abstract A hierarchy of type universes is a rudimentary ingredient in the type theories of many proof assistants to prevent the logical inconsistency resulting from combining dependent functions and the type-in-type axiom. In this work, we argue that a universe hierarchy is not the only option for universes in type theory.
Jonathan Chan 0002, Stephanie Weirich
openaire +4 more sources
, 1999 In this paper the reader will be introduced to type theories (predicative and impredicative, with and without inductive types) by a short section giving theoretical background and by another section with exercises about the calculus of constructions and its fine structure the lambda cube.
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