Results 181 to 190 of about 13,143,476 (301)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The Act-Type Theory of Propositions as a Theory of Cognitive Distinctness
Studia SemiotyczneSoames and others have proposed that propositions are types of acts of predication. Soames has extended the act-type theory by proposing a distinction between direct and mediate predication.
Thomas Hodgson
doaj
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Asymmetric ℤ4 orbifolds of type IIB string theory revisited
We construct freely acting asymmetric ℤ4 orbifolds of type IIB string theory on T5 preserving 24,16 or 8 supercharges in five dimensions. We show that these models are well-defined if the SO(8) lattice is chosen, instead of the SU(2)4 lattice, which was ...
Sub String Theory Cosmology and ElemPart +2 more
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Immersive Technologies in Sport Spectatorship: A Scoping Review of Psychological Responses and Behavioral Intentions. [PDF]
Behav Sci (Basel)Xiong Y, Kim D, Kim K.
europepmc +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
The Theory of the Patient: Toward an Integration of Clinical Reasoning, Causal Inference, and Mechanistic Biology. [PDF]
J Eval Clin PractHorwitz RI.
europepmc +1 more source