Results 71 to 80 of about 8,483 (311)

Projekt i realizacja bazy do „Atlasu gwar wschodniosłowiańskich Białostocczyzny”

Studia z Filologii Polskiej i Słowiańskiej, 2014
Project and realization of database for the "Atlas of East Slavic dialects of Bialystok Region” The article presents issues concerning the project of creation of the Atlas of East Slavic dialects of Bialystok Region (Atlas gwar wschodniosłowiańskich ...
Dorota Krystyna Rembiszewska
doaj   +1 more source

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

Applications and innovations in typeface design for North American Indigenous languages

Book 2 0, 2020
In this contribution, we draw attention to prevailing issues that many speakers of Indigenous North American languages face when typing their languages, and identify examples of typefaces that have been developed and harnessed by historically ...
J. Schillo, Mark Turin
semanticscholar   +1 more source

Acetylation of the Mitochondrial Chaperone GRP75 Governs ER‐Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance

Advanced Science, EarlyView.
Overnutrition exacerbates insulin resistance (IR) and is linked to excessive mitochondrial protein acetylation. However, it remains unclear whether and how mitochondrial protein acetylation influences IR. GCN5L1‐dependent downregulation of GRP75 acetylation at K567/612 consequently enhances ER‐mitochondrial calcium flux and induces ER stress.
Danni Wang, Jiaqi Zhang, Xinyu Yang, Qiqi Zhang, Xiuya Hu, Xin Lu, Hanni Li, Xue Bai, Kai Zhang, Michael N. Sack, Yongsheng Chang, Yingmei Wang, Lingdi Wang, Lu Zhu   +13 more
wiley   +1 more source

Interpretation of RNA Universe and Coding Potential Using IntRNA

Advanced Science, EarlyView.
This study constructs a multi‐channel deep learning framework IntRNA to interpret RNA universe and coding potential. IntRNA consistently performed the best among existing methods in various benchmarks. Moreover, IntRNA’s interpretability is also validated by real‐world analysis, which found some features indicating long‐distance contact between ...
Yunxia Wang, Minjie Mou, Shijie Huang, Wei Zhang, Ziqi Pan, Jing Tang, Yihao Wang, Qingxia Yang, Feng Zhu   +8 more
wiley   +1 more source

Enzalutamide‐Resistant STEAP4+ MyoCAF Secrete Phosphatidylcholine to Foster Progression by Activating Stemness in Hormone‐Sensitive Prostate Cancer

Advanced Science, EarlyView.
Expanding enzalutamide (ENZ) use in hormone‐sensitive prostate cancer (HSPC) faces resistance. Single‐cell profiling identifies therapy‐resistant STEAP4+ myofibroblastic cancer‐associated fibroblast (SETAP4+ myoCAF). These myoCAFs drive resistance via TFE3‐mediated autophagy and PCYT1A‐led phosphatidylcholine overproduction, creating a phospholipid ...
Wenhao Wang, Jing Zhao, Tiewen Li, Guangjian Fan, Jianong Zhang, Chenghao Zheng, Zhiwen Xie, Yu Zhang, Chengling Feng, Tianyu Cao, Jianyin Li, Guomin Ju, Di Cui, Shujie Xia, Bangmin Han   +14 more
wiley   +1 more source

Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories

Advanced Science, EarlyView.
This review presents state‐of‐the‐art metabolic engineering strategies to balance microbial cell growth and product synthesis in biorefineries. It surveys pathway engineering, dynamic genetic circuits, orthogonal control systems, synthetic microbial consortia, and fermentation optimization, alongside integrative modeling approaches.
Linxia Liu, Dongqin Ding, Huiying Wang, Xinyi Ren, Sang Yup Lee, Dawei Zhang   +5 more
wiley   +1 more source

MXene‐Integrated Printed Piezoresistive Flexible Sensors: A Breakthrough in Real‐Time Monitoring for Medical and Smart Applications

Advanced Science, EarlyView.
A chocolate‐inlaid Ag@waffle‐structured MXene is synthesized in this research via template‐directed growth strategy (WSM‐A8). The pressure sensor prepared with the WSM‐A8 presents the highest ΔI/I0 response intensity among the reported MXene‐based piezoresistive sensors with satisfactory sensitivity, outstanding structural stability, and superior ...
Hao‐wen Zhang, Xiang Xu, Di‐wen Jiang, Jie Lu, Yang‐sheng Wang, Zhe‐sheng Feng, Yan Wang   +6 more
wiley   +1 more source

Who is willing to pay a premium for leafy greens produced by indoor agriculture? A comparative choice experiment with US consumers

Agribusiness, EarlyView.
Abstract Indoor agriculture (IA) presents a pathway to producing leafy greens more sustainably by strictly controlling the growing environment, increasing the efficiency of water and land resources use, reducing pesticide application, and enhancing quality characteristics.
Joseph Seong, Simone Valle De Souza, April Athnos, H. Christopher Peterson   +3 more
wiley   +1 more source

The design process seen through the eyes of a type designer

Artifact, 2015
Through a historical overview of the influence designing had on the early days of printing, the paper finds the English printer and typefounder John Baskerville (1706-1775) to be the first real known type designer.
Sofie Beier
doaj   +1 more source