Results 131 to 140 of about 27,708,603 (346)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

WHOLE BRAIN SINGLE NUCLEUS TRANSCRIPTOMICS IN HUMAN: WHAT WE KNOW SO FAR

IBRO Neuroscience Reports, 2023
Kimberly Siletti, Rebecca Hodge, Alejandro Mossi Albiach, Ka Wai Lee, Song-Lin Ding, Lijuan Hu, Peter Lönnerberg, Trygve Bakken, Tamara Casper, Michael Clark, Nick Dee, Jessica Gloe, C. Dirk Keene, Julie Nyhus, Herman Tung, Anna Marie Yanny, Ernest Arenas, Ed Lein, Sten Linnarsson   +18 more
doaj   +1 more source

Treatment of luminal HER2-negative breast cancer: opinion of experts

Лечащий Врач
The discussion, dedicated to the treatment of luminal HER2-negative breast cancer stages II and III, was attended by doctors from St. Petersburg – Maria Leonidovna Makarkina, M.D., oncologist of the outpatient department of the N. P.
E. V. Artemeva, M. L. Makarkina
doaj   +1 more source

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

Nature Genetics, 2019
R. Samstein, Chung-Han Lee, A. Shoushtari, M. Hellmann, R. Shen, Y. Janjigian, D. Barron, A. Zehir, E. Jordan, A. Omuro, T. Kaley, S. Kendall, R. Motzer, A. Hakimi, M. Voss, P. Russo, J. Rosenberg, G. Iyer, B. Bochner, D. Bajorin, H. Al-Ahmadie, J. Chaft, C. Rudin, Gregory Riely, S. Baxi, A. Ho, R. Wong, D. Pfister, J. Wolchok, C. Barker, P. Gutin, C. Brennan, V. Tabar, I. Mellinghoff, L. Deangelis, C. Ariyan, N. Lee, W. Tap, M. Gounder, S. D’Angelo, L. Saltz, Z. Stadler, H. Scher, J. Baselga, P. Razavi, C. Klebanoff, R. Yaeger, N. Segal, G. Ku, R. DeMatteo, M. Ladanyi, N. Rizvi, M. Berger, N. Riaz, D. Solit, T. Chan, L. Morris   +56 more
semanticscholar   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source