Results 101 to 110 of about 784,599 (352)

Older Adults’ Awareness of Community Health and Support Services for Dementia Care [PDF]

The article examines where older adults seek help in caring for a parent with dementia and the factors associated with their identification of community health and support services as sources of assistance.
Brian Hutchison, Joseph Tindale, Kevin Brazil, Jenny Ploeg, Noori Akhtar-Danesh, Jean Lillie, Margaret Denton, Jennifer Millen Plenderleith   +7 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Good practice in health care for migrants: views and experiences of care professionals in 16 European countries [PDF]

, 2011
Background Health services across Europe provide health care for migrant patients every day. However, little systematic research has explored the views and experiences of health care professionals in different European countries.
Majda Lamkaddem, Krasnik Allan, Sandhu, S, Priebe, Stefan, Gaddini, Andrea, Priebe, , S,, Elisabeth Ioannidis, Soares, JJF, Mindaugas Stankunas, Gaddini Andrea, Krasnik, A, Strassmayr, Christa, Wahlbeck, K, Soares, Joaquim,, Greacen Tim, Dias, Sónia Maria Ferreira, Stankunas, M., Sónia Dias, Marija Bogic, Ioannidis, Elisabeth, Krasnik, Allan, Ioannidi, , E,, Priebe, S, Bogic, M, Wahlbeck, K., Marta Welbel, Ioannidis, E., Sandhu,, S,, Lorant, L, Strassmayr, C, Lamkaddem, M, Puigpinosi Riera, Rosa, Lorant, V, Stankunas, Mindaugas, Lorant, V., Rosa Puigpinósi Riera, Allan Krasnik, Riera, Rosa, Wahlbeck Kristian, Lamkaddem, M., Wahlbeck, Kristian, Riera Rosa, Straßmayr, C., Kluge, U., Welbel, M., Dias, Sonia, Kluge, Ulrike, Soares, J.J.F., Straßmayr Christa, Greacen, Tim, Welbel, Marta, Soares, Joaquim, Kluge Ulrike, Dias, S, Sandhu, S., Puigpinósi Riera, R., Gaddini,, A,, Kluge,,  U,, Welbel Marta, Stankunas Mindaugas, Stankunas, M, Lamkaddem Majda, Krasnik, A., Greacen, T, Sima Sandhu, Greacen, T., Bogic Marija, Ioannidis, E, Ioannidis Elisabeth, Sarvary, A, Bogic, M., Kluge, U, Kristian Wahlbeck, Greacen,, T,, Sarvary, A., Lorant Vincent, Puigpinós i Riera, R, Ulrike Kluge, Soares, Joaquim Jf, Priebe, S., Vincent Lorant, Tim Greacen, Soares, Joaquim J. F., Sandhu, Sima, Dias Sónia, Soares Joaquim JF, Priebe Stefan, Gaddini, A., Welbel, M, Stefan Priebe, Bogic, Marija, Riera, RP, Attila Sarvary, Sandhu Sima, Dias, S., Christa Straßmayr, Andrea Gaddini, Dias, Sánia, Lamkaddem, Majda, Lorant, Vincent, Sarvary, Attila, Riera, Rosa Puigpinósi, Soares, Joaquim J F, Sarvary Attila, Joaquim JF Soares, Gaddini, A   +105 more
core   +1 more source

Preferences of Young Adults With First-Episode Psychosis for Receiving Specialized Mental Health Services Using Technology: A Survey Study

JMIR Mental Health, 2015
Background Despite the potential and interest of using technology for delivering specialized psychiatric services to young adults, surprisingly limited attention has been paid to systematically assess their perspectives in this regard.
S. Lal, Jennifer Dell'Elce, Natasha Tucci, R. Fuhrer, R. Tamblyn, A. Malla   +5 more
semanticscholar   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A nationwide mapping of services for high users of emergency departments in England: observational study

BJPsych Bulletin
Aims and method Services for people who are high users of emergency departments (EDs) have developed in a piecemeal fashion, including those embedded within liaison mental health services, over the past decade. We conducted a national survey of all 171
Sonia Saraiva, William Lee, Kate Welsh, Christina M. van der Feltz-Cornelis, Gerlinde Pilkington, Steven Ariss, Stephanie de-la-Haye, Chris Burton, Suzanne Mason, Else Guthrie   +9 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Harm reduction workforce, behavioral health, and service delivery in the USA: a cross-sectional study

Harm Reduction Journal
Background Despite recent financial and policy support for harm reduction in the USA, information on the types of workers within organizations who design, implement, and actualize harm reduction services remains nascent.
Lisa de Saxe Zerden, Orrin D. Ware, Brooke N. Lombardi, Brianna M. Lombardi   +3 more
doaj   +1 more source

Estimating benefit equity of government health subsidy in healthcare Services in Shandong Province, China: a cross-sectional study

International Journal for Equity in Health, 2018
Background Government health subsidy (GHS) is an effective tool to improve population health in China. Ensuring an equitable allocation of GHS, particularly among the poorer socio-economic groups, is a major goal of China’s healthcare reform.
Wenzhe Qin, Lingzhong Xu, Jiajia Li, Long Sun, Gan Ding, Hui Shao, Ningze Xu   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source