Results 81 to 90 of about 2,655,712 (307)

Referral trends in mental health services for adults with intellectual disability and autism spectrum disorders \ud \ud [PDF]

, 2007
Researchers have paid increasing attention to mental \ud health issues in adults with autism spectrum disorders (ASDs) over the \ud last decades. However, little is known about how rates of clinical \ud referrals,types of mental health diagnoses and ...
Tsakanikos, Elias
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Estimating benefit equity of government health subsidy in healthcare Services in Shandong Province, China: a cross-sectional study

International Journal for Equity in Health, 2018
Background Government health subsidy (GHS) is an effective tool to improve population health in China. Ensuring an equitable allocation of GHS, particularly among the poorer socio-economic groups, is a major goal of China’s healthcare reform.
Wenzhe Qin, Lingzhong Xu, Jiajia Li, Long Sun, Gan Ding, Hui Shao, Ningze Xu   +6 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Harm reduction workforce, behavioral health, and service delivery in the USA: a cross-sectional study

Harm Reduction Journal
Background Despite recent financial and policy support for harm reduction in the USA, information on the types of workers within organizations who design, implement, and actualize harm reduction services remains nascent.
Lisa de Saxe Zerden, Orrin D. Ware, Brooke N. Lombardi, Brianna M. Lombardi   +3 more
doaj   +1 more source

The use of routine outcome measures in two child and adolescent mental health services: a completed audit cycle [PDF]

, 2013
Background: Routine outcome measurement (ROM) is important for assessing the clinical effectiveness of health services and for monitoring patient outcomes.
A Willis, A-M Martin, AF Garland, American Psychiatric Association, BF Chorpita, C Conners, C Johnston, Charlotte L Hall, Chris Hollis, D Law, D Shaffer, Department of Health, Department of Health, DR Hatfield, DR Hatfield, E Garralda, EM Garralda, EM Garralda, G Baruch, J Attride-Stirling, J Oates, J Truman, JL Close-Goedjen, John Taylor, K Hanssen-Bauer, Kapil Sayal, Karen Newell, L Bickman, Laurence Baldwin, LD Johnson, LS Kiger, M Barkham, Maria Moldavsky, Michael Marriott, R Goodman, R Goodman, R Goodman, R Goodman, S Gowers, S Timimi, SD Miller, SG Gowers, T Ford   +42 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Health care needs and service use among male prison inmates in the United States: A multi-level behavioral model of prison health service utilization

Health & Justice, 2017
Background The purpose of this study is to apply Andersen’s Behavioral Model of Health Service Use to men’s prisons to assess the direct and indirect effects of inmate predisposing characteristics through multiple types of need.
Kathryn M. Nowotny
doaj   +1 more source