Results 71 to 80 of about 2,733,713 (347)
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Measuring and Comparing Health System Delays in Leprosy Detection Based on the First Healthcare Service Visit in Tegal Regency, Indonesia [PDF]
BIO Web of ConferencesThe prevalence of leprosy patients with disabilities among new cases in Tegal Regency was high in 2021, reaching 10%. This problem is due to the delays in the diagnosis and treatment of leprosy, including health system delays associated with patients ...
Dharmawan Yudhy, Mawarni Atik, Dharminto
doaj +1 more source
BMC Public Health, 2006 BackgroundOnly a minority of adolescents reporting symptoms above case-levels on screenings for mental health seeks and receives help from specialist health services.
H. Zachrisson +2 more
semanticscholar +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Patterns of service utilization among youth with substance use service need: a cohort study
Substance Abuse Treatment, Prevention, and Policy, 2023 Background Integrated youth services (IYS) are vital to addressing the needs of youth who use substances. Evidence on the characteristics of youths accessing these services and the types of services accessed have been limited.
Nikki Ow +6 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Does service-level spending show evidence of selection across health plan types? [PDF]
Applied Economics, 2013 We provide an explanation for the widespread finding that capitated managed care plans attract comparatively healthy, low cost enrollees relative to traditional unmanaged plans. Using disaggregated commercial insurance claims from the Thomson-Reuters MarketScan database, we show that managed care plans spend proportionally less on those types of ...
Randall P. Ellis +2 more
openaire +1 more source
The Housing Needs of Chicago's Aging LGBT Population [PDF]
, 2007 Lesbian, gay, bisexual, and transgender (LGBT) seniors face challenges common to all aging adults such as health problems, dwindling finances, ageism, and loneliness.
core
Exploring Challenges in Conducting E-Mental Health Research Among Asian American Women [PDF]
, 2018 In this discussion paper, we explore the challenges of conducting e-mental health intervention research among Asian American women and propose a model for addressing these barriers.
Acupan, Alvin Ryan +4 more
core +2 more sources