Results 1 to 10 of about 750,979 (197)

APOBEC3 activity and DNA polymerase-ε deficiency are associated with distinct IDH1 R132 hotspot mutations. [PDF]

Mol Oncol
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Butler KE, Lone BA, Unal E, Banday AR.
europepmc   +2 more sources

Translating whole-genome doubling into precision medicine in cancer. [PDF]

Mol Oncol
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Lee S, Lim J, Bhin J.
europepmc   +2 more sources

Leiomyoadenomatoid tumors: A type of rare benign epididymal tumor

Urology Case Reports, 2021
Primary tumors of the epididymis are mostly benign in nature, and the most common type is adenomatoid tumors followed by leiomyomas. Leiomyoadenomatoid tumors are very rare benign epididymal neoplasms composed of two components: gland-like structures lined by cuboidal cells and bundles of smooth muscle components.
Nasser Almohaya, Mohammed Almansori, Mohammed Sammour, Abdulbari Bin Ajjaj, Mohamed Tahar Yacoubi   +4 more
openaire   +3 more sources

Salivary Gland-type Tumors of the Lung [PDF]

Archives of Pathology & Laboratory Medicine, 2021
Context.— Salivary gland-type tumors (SGTs) of the lung represent a distinct group of lung neoplasms. Pulmonary SGTs often pose diagnostic challenges, especially in small biopsy and cytology samples because of limited sample volume and overlapping morphology among pulmonary SGTs, metastatic SGTs of head and neck
Minhua, Wang, Syed, Gilani, Haodong, Xu, Guoping, Cai   +3 more
openaire   +2 more sources

A NAIL TUMOR OF UNUSUAL TYPE [PDF]

Archives of Dermatology and Syphilology, 1922
In January, 1921, while delivering a clinical lecture before the Douglas County Medical Society, at Lawrence, Kansas, I encountered a case of nail disorder which was entirely new to me. REPORT OF CASES Case 1.— The patient was a young woman, under the care of my friend, Dr. H. L. Chambers, and the affection, which involved the nail of the left thumb,
openaire   +2 more sources

Molecular classification of multiple tumor types [PDF]

Bioinformatics, 2001
Abstract Using gene expression data to classify tumor types is a very promising tool in cancer diagnosis. Previous works show several pairs of tumor types can be successfully distinguished by their gene expression patterns (Golub et al. 1999, Ben-Dor et al. 2000, Alizadeh et al. 2000).
Chen-Hsiang Yeang, Sridhar Ramaswamy, Pablo Tamayo, Sayan Mukherjee 0001, Ryan M. Rifkin, Michael Angelo, Michael Reich, Eric S. Lander, Jill P. Mesirov, Todd R. Golub   +9 more
openaire   +2 more sources

Adult‐type granulosa cell tumor: An unusual testicular tumor [PDF]

Clinical Case Reports, 2021
Abstract Adult type granulosa cell tumours are extremely rare. Albeit mostly benign, 10% have malignant potential associated with unfavorable pathological features. The present case with the longest history duration, shows that size alone may not necessarily be unfavorable prognosticator when not associated with other factors.
Alain Mwamba Mukendi, Joelle Bukumbabu Mukendi, Ahsan Ahmad, Nompumelelo Mtshali   +3 more
openaire   +3 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Brain tumors in neurofibromatosis type 1 [PDF]

Neuro-Oncology Advances, 2019
AbstractAbstractAs a cancer predisposition syndrome, individuals with neurofibromatosis type 1 (NF1) are at increased risk for the development of both benign and malignant tumors. One of the most common locations for these cancers is the central nervous system, where low-grade gliomas predominate in children.
Amanda De Andrade Costa, David H Gutmann
openaire   +3 more sources