Results 21 to 30 of about 750,979 (197)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Juvenile Type Granulosa Cell Tumor

Serbian Journal of Experimental and Clinical Research, 2018
Abstract Granulosa cell tumor is a type of neoplasm, which represents 2-5% of all ovarian cancers. About 5% of these tumors are juvenile- type and usually occur to girls before puberty and to women younger than thirty years of age. There are signs premature puberty or premature emergence of secondary sexual characteristics with irregular
Andric B., Arsenijevic P., Jović N., Arsenijevic, Nebojsa, Protrka, Zoran   +4 more
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

Science, 2020
Profiling tumor bacteria Bacteria are well-known residents in human tumors, but whether their presence is advantageous to the tumors or to the bacteria themselves has been unclear. As an initial step toward addressing this question, Nejman et al.
Nejman, Deborah, Livyatan, Ilana, Fuks, Garold, Gavert, Nancy, Zwang, Yaara, Geller, Leore T., Rotter-Maskowitz, Aviva, Weiser, Roi, Mallel, Giuseppe, Gigi, Elinor, Meltser, Arnon, Douglas, Gavin M., Kamer, Iris, Gopalakrishnan, Vancheswaran, Dadosh, Tali, Levin-Zaidman, Smadar, Avnet, Sofia, Atlan, Tehila, Cooper, Zachary A., Arora, Reetakshi, Cogdill, Alexandria P., Khan, Md Abdul Wadud, Ologun, Gabriel, Bussi, Yuval, Weinberger, Adina, Lotan-Pompan, Maya, Golani, Ofra, Perry, Gili, Rokah, Merav, Bahar-Shany, Keren, Rozeman, Elisa A., Blank, Christian U., Ronai, Anat, Shaoul, Ron, Amit, Amnon, Dorfman, Tatiana, Kremer, Ran, Cohen, Zvi R., Harnof, Sagi, Siegal, Tali, Yehuda-Shnaidman, Einav, Gal-Yam, Einav Nili, Shapira, Hagit, Baldini, Nicola, Langille, Morgan G. I., Ben-Nun, Alon, Kaufman, Bella, Nissan, Aviram, Golan, Talia, Dadiani, Maya, Levanon, Keren, Bar, Jair, Yust-Katz, Shlomit, Barshack, Iris, Peeper, Daniel S., Raz, Dan J., Segal, Eran, Wargo, Jennifer A., Sandbank, Judith, Shental, Noam, Straussman, Ravid   +60 more
openaire   +4 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An evolutionary–type model for tumor immunotherapy

IFAC-PapersOnLine, 2015
In this paper we propose a new dynamical model for describing the interactions between immune and tumor cells. This model captures the effects of the tumor cells on the immune system and viceversa, through predator-prey competition terms. Additionally, it incorporates the immune system's mechanism to produce hunting immune cells, which makes the model ...
Doban, A.I., Lazar, M.
openaire   +1 more source