Results 21 to 30 of about 1,056,458 (160)

T1-mapping characterization of two tumor types

Biophysical Reports
T1 mapping is a quantitative method to characterize tissues with magnetic resonance imaging in a quick and efficient manner. It utilizes the relaxation rate of protons to depict the underlying structures within the imaging frame. While T1-mapping techniques are used with some frequency in areas such as cardiac imaging, their application for ...
Macy Marie Payne, Ivina Mali, Tej B. Shrestha, Matthew T. Basel, Sarah Timmerman, Marla Pyle, Jan Sebek, Punit Prakash, Stefan H. Bossmann   +8 more
openaire   +2 more sources

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

Science, 2020
Profiling tumor bacteria Bacteria are well-known residents in human tumors, but whether their presence is advantageous to the tumors or to the bacteria themselves has been unclear. As an initial step toward addressing this question, Nejman et al.
Nejman, Deborah, Livyatan, Ilana, Fuks, Garold, Gavert, Nancy, Zwang, Yaara, Geller, Leore T., Rotter-Maskowitz, Aviva, Weiser, Roi, Mallel, Giuseppe, Gigi, Elinor, Meltser, Arnon, Douglas, Gavin M., Kamer, Iris, Gopalakrishnan, Vancheswaran, Dadosh, Tali, Levin-Zaidman, Smadar, Avnet, Sofia, Atlan, Tehila, Cooper, Zachary A., Arora, Reetakshi, Cogdill, Alexandria P., Khan, Md Abdul Wadud, Ologun, Gabriel, Bussi, Yuval, Weinberger, Adina, Lotan-Pompan, Maya, Golani, Ofra, Perry, Gili, Rokah, Merav, Bahar-Shany, Keren, Rozeman, Elisa A., Blank, Christian U., Ronai, Anat, Shaoul, Ron, Amit, Amnon, Dorfman, Tatiana, Kremer, Ran, Cohen, Zvi R., Harnof, Sagi, Siegal, Tali, Yehuda-Shnaidman, Einav, Gal-Yam, Einav Nili, Shapira, Hagit, Baldini, Nicola, Langille, Morgan G. I., Ben-Nun, Alon, Kaufman, Bella, Nissan, Aviram, Golan, Talia, Dadiani, Maya, Levanon, Keren, Bar, Jair, Yust-Katz, Shlomit, Barshack, Iris, Peeper, Daniel S., Raz, Dan J., Segal, Eran, Wargo, Jennifer A., Sandbank, Judith, Shental, Noam, Straussman, Ravid   +60 more
openaire   +4 more sources

Preclinical Analysis of JAA-F11, a Specific Anti-Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging. [PDF]

, 2018
The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and normal tissue ...
Adams, Julia, Fisk, John C, Ghazal, Diala, Jessee, Joseph, Johnson, Holly, Karacosta, Loukia G, Koury, Steven, Ludwig, Rachel, Olson, James R, Rittenhouse-Olson, Kate, Roy, Rene, Sajjad, Munawwar, Tati, Swetha, Turner, Bradley   +13 more
core   +2 more sources

EVALUATING THE THERAPEUTIC EFFICACY OF RESTORING WILD-TYPE P53 ACTIVITY IN P53-MUTANT TUMORS [PDF]

, 2017
The p53 transcription factor is the most frequently altered in human cancers usually via missense mutations that undermine its transcriptional activity. Clinically, TP53 mutations have been shown to be remarkably predictive of refractoriness to treatment,
Larsson, Connie A
core   +1 more source

The influence of anisotropic growth and geometry on the stress of solid tumors [PDF]

, 2017
Solid stresses can affect tumor patho-physiology in at least two ways: directly, by compressing cancer and stromal cells, and indirectly, by deforming blood and lymphatic vessels.
Bravo-Castillero, Julián, Conci, Aura, García-Reimbert, Catherine, Guinovart-Díaz, Raúl, Merodio, José, Penta, Raimondo, Ramírez-Torres, Ariel, Rodríguez-Ramos, Reinaldo, Sabina, Federico J., Sevostianov, Igor   +9 more
core   +1 more source

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles [PDF]

, 1996
Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from Drosophila to humans. A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of
Aster, Jon C., Baltimore, David, Hasserjian, Robert P., Pear, Warren S., Scott, Martin L., Sklar, Jeffrey, Soffer, Benny   +6 more
core  

Pan-cancer classifications of tumor histological images using deep learning [PDF]

, 2020
Histopathological images are essential for the diagnosis of cancer type and selection of optimal treatment. However, the current clinical process of manual inspection of images is time consuming and prone to intra- and inter-observer variability. Here we
Caruana, Dennis, Chuang, Jeffrey H., Farahmand, Saman, Foroughi pour, Ali, Namburi, Sandeep, Noorbakhsh, Javad, Rimm, David, Soltanieh-Ha, Mohammad, Zarringhalam, Kourosh   +8 more
core   +1 more source

Practical guidance for applying the ADNEX model from the IOTA group to discriminate between different subtypes of adnexal tumors. [PDF]

, 2015
All gynecologists are faced with ovarian tumors on a regular basis, and the accurate preoperative diagnosis of these masses is important because appropriate management depends on the type of tumor. Recently, the International Ovarian Tumor Analysis (IOTA)
Anthoulakis, C, Bourne, T, Froyman, W, Kaijser, J, Landolfo, C, Timmerman, D, Van Calster, B, Van Hoorde, K, Vergote, I, Wynants, L   +9 more
core   +1 more source

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer [PDF]

, 2014
The underpinnings of STAT3 hyperphosphorylation resulting in enhanced signaling and cancer progression are incompletely understood. Loss-of-function mutations of enzymes that dephosphorylate STAT3, such as receptor protein tyrosine phosphatases, which ...
Bahar, Ivet, Du, Yu, Garraway, Levi A., General, Ignacio, Gilbert, Breean R., Grandis, Jennifer R., Hammerman, Peter S., Hritz, Jozef, Johnson, Daniel E., Ju, Zhenlin, Li, Hua, Lu, Yiling, Lui, Vivian Wai Yan, Mills, Gordon B., Ng, Patrick Kwok-Shing, Pendleton, Kelsey P., Peyser, Noah D., Vries, John K., Wang, Lin, Wang, Zhenghe, Xiao, Xiao, Zeng, Yan   +21 more
core   +1 more source

NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations. [PDF]

, 2013
Inactivating germline mutations in the tumor suppressor gene NF2 cause the hereditary syndrome neurofibromatosis 2, which is characterized by the development of neoplasms of the nervous system, most notably bilateral vestibular schwannoma.
Angelo, Laura S, Kurzrock, Razelle, Schroeder, Rebecca Dunbar   +2 more
core   +3 more sources