Results 21 to 30 of about 64,479 (182)

Antibiotic Resistant and Plasmid Conjugative Study of Salmonella typhi

Jurnal Teknologi Laboratorium, 2018
The emergence of multi-drug resistant (MDR) bacteria has endangered the efficacy of antibiotics treatment of pathogenic bacteria worldwide. The aim of this research was to investigate the incidence of Salmonella enterica serovar Typhi in Duhok city, Iraq.
Waleed Haji Saeed Akreyi, Samira Younis Yousif, Mahde Assafi   +2 more
doaj   +1 more source

Salmonella enterica serovar Typhi uses two type 3 secretion systems to replicate in human macrophages and colonize humanized mice

mBio, 2023
Salmonella enterica serovar Typhi (S. Typhi) is a human-restricted pathogen that replicates in macrophages. In this study, we investigated the roles of the S.
Meagan Hamblin, Ruth Schade, Ramya Narasimhan, Denise M. Monack   +3 more
doaj   +1 more source

Evolutionary History of Salmonella Typhi [PDF]

Science, 2006
For microbial pathogens, phylogeographic differentiation seems to be relatively common. However, the neutral population structure of Salmonella enterica serovar Typhi reflects the continued existence of ubiquitous haplotypes over millennia.
Roumagnac, P., Weill, F., Dolecek, C., Baker, S., Brisse, S., Chinh, N., Le, T., Acosta, C., Farrar, J., Dougan, G., Achtman, M.   +10 more
openaire   +4 more sources

Variable carbon catabolism among Salmonella enterica serovar Typhi isolates. [PDF]

PLoS ONE, 2012
BACKGROUND: Salmonella enterica serovar Typhi (S. Typhi) is strictly a human intracellular pathogen. It causes acute systemic (typhoid fever) and chronic infections that result in long-term asymptomatic human carriage. S.
Lay Ching Chai, Boon Hong Kong, Omar Ismail Elemfareji, Kwai Lin Thong   +3 more
doaj   +1 more source

A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure

eLife, 2016
The interplay between bacterial antimicrobial susceptibility, phylogenetics and patient outcome is poorly understood. During a typhoid clinical treatment trial in Nepal, we observed several treatment failures and isolated highly fluoroquinolone-resistant
Duy Pham Thanh, Abhilasha Karkey, Sabina Dongol, Nhan Ho Thi, Corinne N Thompson, Maia A Rabaa, Amit Arjyal, Kathryn E Holt, Vanessa Wong, Nga Tran Vu Thieu, Phat Voong Vinh, Tuyen Ha Thanh, Ashish Pradhan, Saroj Kumar Shrestha, Damoder Gajurel, Derek Pickard, Christopher M Parry, Gordon Dougan, Marcel Wolbers, Christiane Dolecek, Guy E Thwaites, Buddha Basnyat, Stephen Baker   +22 more
doaj   +1 more source

Genomic Insights Into Spatiotemporal Dynamics of Acquired Azithromycin Resistance Genes in Salmonella Strains Worldwide

Food Safety and Health, EarlyView.
ABSTRACT Azithromycin has been used for clinical invasive infections caused by fluoroquinolone‐ and third‐generation cephalosporin‐resistant Salmonella, and mass drug administration with azithromycin has been used to reduce under‐5 mortality in children in some countries.
Yuhang Pei, Mengqi Qu, Ziru Yang, Xuebin Xu, Yanan Wang   +4 more
wiley   +1 more source

Temporal fluctuation of multidrug resistant salmonella typhi haplotypes in the mekong river delta region of Vietnam. [PDF]

PLoS Neglected Tropical Diseases, 2011
typhoid fever remains a public health problem in Vietnam, with a significant burden in the Mekong River delta region. Typhoid fever is caused by the bacterial pathogen Salmonella enterica serovar Typhi (S.
Kathryn E Holt, Christiane Dolecek, Tran Thuy Chau, Pham Thanh Duy, Tran Thi Phi La, Nguyen Van Minh Hoang, Tran Vu Thieu Nga, James I Campbell, Bui Huu Manh, Nguyen Van Vinh Chau, Tran Tinh Hien, Jeremy Farrar, Gordon Dougan, Stephen Baker   +13 more
doaj   +1 more source

Tiny carriers, big impact: How Fusobacterium nucleatum extracellular vesicles drive oral diseases and beyond

Interdisciplinary Medicine, EarlyView.
This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma, Jiahui Huang, Yitong Chen, Haoxuan Wang, Hang Zou, Wanghong Zhao, Zilong Deng   +6 more
wiley   +1 more source

Synthetic O‐Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non‐Typhoidal Salmonella Serovars

Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.
A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan, Changxin Huo, Soham Maity, Herbert Kavunja, Rachel Moszyk, Cameron Talbot, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +2 more sources

Transcriptional profiling links unique human macrophage phenotypes to the growth of intracellular Salmonella enterica serovar Typhi

Scientific Reports
Macrophages provide a crucial environment for Salmonella enterica serovar Typhi (S. Typhi) to multiply during typhoid fever, yet our understanding of how human macrophages and S. Typhi interact remains limited.
Ruth Schade, Daniel S. C. Butler, Joy A. McKenna, Blanda Di Luccia, Vida Shokoohi, Meagan Hamblin, Trung H. M. Pham, Denise M. Monack   +7 more
doaj   +1 more source