Results 31 to 40 of about 2,520 (267)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A New Typification Method for Combined Linear Building Patterns with the Resolution of Spatial Conflicts

ISPRS International Journal of Geo-Information
Typification is a crucial generalization operator for maintaining the structure of building patterns in map generalization. However, in densely built-up areas, the structure of building patterns is complicated, and spatial conflicts exist not only within
Ying Tong, Qingsheng Guo, Wei Zhu, Chuanbang Zheng   +3 more
doaj   +1 more source

Socio-economic characterization of the traditional agroforestry cacao system (Theobroma cacao L.)

Revista de Ciencias Agrícolas, 2021
Cacao farmers face many challenges to increase yield while adjusting their farms to future environmental and socio-economic uncertainties. Improving the management practices of cacao (Theobroma cacao L.) cultivation systems requires knowledge of their
William Ballesteros-Possú, Jorge Fernando Navia E., Jesús-Geovanny Solarte-Guerrero   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Considerations and distributional innovations for some taxa of the genus Parapholis (Poaceae) in the Adriatic basin with special reference to Parapholis strigosa, for which a new infraspecific taxon is proposed

Natural History Sciences
The distribution of Parapholis strigosa (Dumort.) C.E.Hubb. in the Adriatic basin has been analysed. After the investigations by Hylander and Runemark, further collections were made, particularly during the years 1991-2002, and in 2017-2018 limited to ...
Piero Cuccuini, Lorella Dell’Olmo, Stefano Dominici   +2 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Synopsis and lectotypification of Solanum (Solanaceae) species endemic in the West Indies

Anales del Jardín Botánico de Madrid, 2009
The West Indies (Bahamas, Greater and Lesser Antilles) is an area of high species richness and more importantly, species-level endemism in many groups. Solanum (Solanaceae) is diverse in the region with 25 endemic species (S.
Sandra Knapp
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source