Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Adherence to antidiabetic medication and factors associated with non-adherence among patients with type-2 diabetes mellitus in two regional hospitals in Cameroon [PDF]
, 2019 Léopold Ndemnge Aminde +6 more
openalex +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Concentrations and resorption patterns of 13 nutrients in different plant functional types in the karst region of south-western China [PDF]
, 2014 Changcheng Liu +4 more
openalex +1 more source
Knowledge of young people living with type 1 diabetes and their caregivers about its management [PDF]
, 2022 Bernard Afriyie Owusu +3 more
openalex +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Soft kidney allocation improves HLA matching and maintains allocation order
Communications MedicineBackground Kidney allocation scores aim to balance transplant efficacy and equity but often deprioritize Human Leukocyte Antigen (HLA) matching, leading to reduced graft lifespan and a higher risk of donor-specific antibodies (DSA). This study introduces
Sapir Israeli +9 more
doaj +1 more source
A model-based approach to hypermedia design. [PDF]
This paper introduces the MESH approach to hypermedia design, which combines established entity-relationship and object-oriented abstractions with proprietary concepts into a formal hypermedia data model. Uniform layout and link typing specifications can
Lemahieu, Wilfried
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Contribution of Common Genetic Variation to the Risk of Type 2 Diabetes in the Mexican Mestizo Population [PDF]
, 2012 Marco Alberto Gamboa-Meléndez +18 more
openalex +1 more source