Results 151 to 160 of about 14,267,916 (344)

Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms.

Proceedings of the National Academy of Sciences of the United States of America, 1998
M. Maiden, J. Bygraves, E. Feil, G. Morelli, J. Russell, R. Urwin, Qing Zhang, Jiaji Zhou, Kerstin Zurth, D. Caugant, I. Feavers, M. Achtman, B. Spratt   +12 more
semanticscholar   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Functional Characterization of Alternative Splicing in the C Terminus of L-type CaV1.3 Channels [PDF]

, 2011
Bao Zhen Tan, Fengli Jiang, Ming Tan, Dejie Yu, Hua Huang, Yiru Shen, Tuck Wah Soong   +6 more
openalex   +1 more source

Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity

Journal of Clinical Microbiology, 1988
P. Hunter, M. A. Gaston
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection [PDF]

, 2017
Amanda J. Lee, Branson Chen, Marianne V. Chew, Nicole G. Barra, Mira M. Shenouda, Tina Nham, Nico van Rooijen, Manel Jordana, Karen Mossman, Robert D. Schreiber, Matthias Mack, Ali A. Ashkar   +11 more
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

16S rDNA Typing of Salmonella Typhi Strains from Different Geographical Locations in Sumba Island East Nusa Tenggara Indonesia

Microbiology Indonesia, 2013
A total of thirteen isolates representative of Salmonella Typhi from different geographical locations in Sumba Island, East Nusa Tenggara, Indonesia were identified by 16S rDNA gene sequences.
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Path-Based Attention Neural Model for Fine-Grained Entity Typing

, 2018
Fine-grained entity typing aims to assign entity mentions in the free text with types arranged in a hierarchical structure. Traditional distant supervision based methods employ a structured data source as a weak supervision and do not need hand-labeled ...
Cai, Pengshan, Cheng, Xueqi, Jia, Yantao, Li, Manling, Wang, Yuanzhuo, Zhang, Denghui   +5 more
core   +1 more source