Results 241 to 250 of about 14,267,916 (344)

Sibship reconstruction from genetic data with typing errors.

Genetics, 2004
Jinliang Wang
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Pairwise Paternity Assignment With Forward-Backward Simulations: Refining CERVUS Using Trio-Based Likelihood and Locus-Specific Error Rates. [PDF]

Ecol Evol
Amiri Roudbar M, Mousavi SF, Akbarzadeh M, Brounts SH, Momen M.   +4 more
europepmc   +1 more source

Typing is writing: Linguistic properties modulate typing execution

Psychonomic Bulletin & Review, 2016
S. Pinet, J. Ziegler, F. Alario
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Correction to "Antimicrobial Resistance, Multilocus Sequence, and Spa Typing of <i>Staphylococcus aureus</i> Isolated From Retail Raw Meat Products". [PDF]

Biomed Res Int
europepmc   +1 more source

Are fluent letter dyads really fluent? An update on objective and subjective motor fluency in an Italian student population. [PDF]

Cogn Res Princ Implic
Stockner M, Mazzoni G, Ianì F.
europepmc   +1 more source

Extended-Spectrum β-Lactamases of the CTX-M Type Now in Switzerland

, 2007
Marie-Frédérique Lartigue, Catherine Zinsius, Aline Wenger, Jacques Billé, Laurent Poirel, Patrice Nordmann   +5 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Development and validation of a core-genome multilocus sequence typing scheme for <i>Legionella longbeachae</i>. [PDF]

Microb Genom
Miller H, Harte D, Khokryakova I, Jordan R, Bradshaw A, Wang J, Winter D.   +6 more
europepmc   +1 more source