Results 311 to 320 of about 1,534,933 (399)

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Correction: Receptor tyrosine kinase inhibitor sunitinib as novel immunotherapy to inhibit myeloid-derived suppressor cells for treatment of endometriosis. [PDF]

Front Immunol
He Y, Hung SW, Liang B, Zhang R, Gao Y, Chu CY, Zhang T, Xu H, Chung JPW, Wang CC.   +9 more
europepmc   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, EarlyView.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Lipid-Protein Interplay in the Regulation of Receptor Tyrosine Kinases. [PDF]

Cells
Domenichini M, Gogna A, Maggi C, Moreschi E, Ventura A, Codibue M, Grillo E, Corsini M, Mitola S.   +8 more
europepmc   +1 more source

Accurate affinity models for SH2 domains from peptide binding assays and free-energy regression. [PDF]

Protein Sci
Gagoski D, Rube HT, Rastogi C, Melo LAN, Li X, Voleti R, Shah NH, Bussemaker HJ.   +7 more
europepmc   +1 more source

Adsorption of serum components on Ag colloids: on the biochemical interpretation of surface-enhanced Raman spectra of human serum. [PDF]

Anal Bioanal Chem
Gobbato R, Fornasaro S, Sergo V, Bonifacio A.   +3 more
europepmc   +1 more source

Metabolic plasticity supports a flexible nutritional symbiosis in Cardiocondyla ants

Henry L, Cunningham P, Martín-Durán J, Oettler J, Schultner E, Halitschke R, Engl T, Kaltenpoth M.   +7 more
europepmc   +1 more source

Altered tyrosine metabolism and B lymphocyte profiles are associated with disease severity in pediatric anti-NMDAR encephalitis: a cross-sectional study. [PDF]

Eur J Pediatr
Cao D, Zhang M, Ma C, Ouyang S, Jiao H, Miao S, Liu Z, Li G, Li D, Sun J, Zhang J.   +10 more
europepmc   +1 more source

Proteomic Analysis of PTEN-Deficient Cells Reveals Src-Mediated Upregulation of EphA2 and Therapeutic Potential of Dual Inhibition. [PDF]

Mol Cell Proteomics
Wang Q, Kong X, Song H, Wang L, Li L, Hou X, Renuse S, Zahari MS, Cheng R, Khan MKH, Wang J, Mangalaparthi K, Fang L, Lotan TL, Park BH, Weroha SJ, Zhou H, Pandey A, Wu X.   +18 more
europepmc   +1 more source

Correction: Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase. [PDF]

Biochem J
europepmc   +1 more source