Results 91 to 100 of about 537,284 (311)

Oncogenic RET Kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans

, 2014
To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry.
Martínez-Torres, R.J., Goodman, K., Plaza-Menacho, I., Barnouin, K., Mouilleron, S., Borg, A., Knowles, P.P., Murray-Rust, J., McDonald, Neil Q.   +8 more
core   +1 more source

Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo [PDF]

, 2007
Endothelial cell survival is indispensable to maintain endothelial integrity and initiate new vessel formation. We investigated the role of SHP-2 in endothelial cell survival and angiogenesis in vitro as well as in vivo.
Groesser, Leopold, Walzog, Barbara, Gloe, Torsten, Sohn, Hae-Young, Krötz, Florian, Plank, Christian, Pohl, Ulrich, Hellwig, Nicole, Mannell, Hanna   +8 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Syk-mediated translocation of PI3Kδ to the leading edge controls lamellipodium formation and migration of leukocytes [PDF]

, 2007
The non-receptor tyrosine kinase Syk is mainly expressed in the hematopoietic system and plays an essential role in β2 integrin-mediated leukocyte activation.
Jakus, Zoltán, Walzog, Barbara, Cornelia Then, Scharffetter-Kochanek, Karin, Then, Cornelia, Victor L. J. Tybulewicz, Barbara Walzog, Ronald Gerstl, Zoltán Jakus, Sindrilaru, Anca, Jürgen Schymeinsky, Schymeinsky, Juergen, Anca Sindrilaru, Gerstl, Ronald, Tybulewicz, Victor L. J., Victor L J Tybulewicz, Karin Scharffetter-Kochanek, Schymeinsky, Jürgen, Tybulewicz, Victor LJ   +18 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Activation of Tyrosine Kinases in Cancer

The Oncologist, 2003
Abstract Learning Objectives After completing this course, the reader will be able to: Identify the advantages of small molecule inhibitors. Explain the significant role that tyrosine kinase plays in signal transduction. Describe the tyrosine kinase inhibitors clinical data.
Gordana, Vlahovic, Jeffrey, Crawford
openaire   +2 more sources

Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer [PDF]

, 2007
Tumor angiogenesis is a process that requires migration, proliferation, and differentiation of endothelial cells. We hypothesized that decrease in pancreatic tumor growth due to inhibition of src activity is associated with the inability of src kinase to
Ischenko, Ivan
core  

The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses

, 2007
The molecular mechanisms whereby the CD45 tyrosine phosphatase (PTPase) regulates T cell receptor (TCR) signaling responses remain to be elucidated. To investigate this question, we have reconstituted CD45 (encoded by Ptprc)-deficient mice, which display
Cooper, Joanne C, Alexander, Denis R, Cassady-Cain, Robin L., Salmond, Robert J., Tandon, Panna, Roche-Molina, Marta, Carret, Céline K., Holmes, Nick, McNeill, Louise, Cassady-Cain, Robin, Cooper, Joanne C., Alexander, Denis R., Carret, Celine K   +12 more
core   +1 more source

FLT3 Mutation as a Significant Prognostic Marker in de novo Acute Myeloid Leukemia Patients: Incidence, Distribution and Association with Cytogenetic Findings in a Study from South India

Middle East Journal of Cancer, 2014
Background: Fms-like tyrosine kinase 3 is a tyrosine kinase receptor that plays an important role in proliferation and differentiation of hematopoietic stem cells. Internal tandem duplication and tyrosine kinase domain mutation are the two most common
Santhi Sarojam, Sangeetha Vijay, Sureshkumar Raveendran, Jayadevan Sreedharan, Geetha Narayanan, Hariharan Sreedharan   +5 more
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source