Results 271 to 280 of about 537,284 (311)

Protein tyrosine kinases and cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1997
4. Tyrosine kinase activation by mutation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . F222 4.1. BCR–ABL and human leukemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . F222 4.2. TEL–ABL and human leukemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . F224 4.3.
K S, Kolibaba, B J, Druker
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Superoxide generation and tyrosine kinase

Biochemistry and Cell Biology, 2000
NADPH oxidase is a multi-subunit enzyme complex responsible for superoxide generation in many cells, for example, B-lymphocytes and osteoclasts. NADPH oxidase is localized on the cell surface and generates superoxide extracellularly. After synthesis, components of this oxidase are transported to the cell membrane where the functional NADPH oxidase ...
S, Yang, M, Hardaway, G, Sun, W L, Ries, L L, Key   +4 more
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Neoadjuvant Tyrosine Kinase Inhibitors

Thoracic Surgery Clinics
Neoadjuvant tyrosine kinase inhibitor (TKI) therapy has appeal given the potential for early systemic disease control and tumor downstaging prior to surgery. Until recently, data has have come from smaller series with outcomes from larger trials, including NeoADAURA, ALNEO, and NAUTIKA1, reporting early results. Neoadjuvant use of TKI has been shown to
Gavitt A, Woodard, Ryan J, Kramer, Collin M, Blakely   +2 more
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Abl tyrosine protein kinase

Seminars in Immunology, 1995
Mammalian c-Abl belongs to an evolutionary conserved family of non-receptor tyrosine kinases. It is distributed both in the cytoplasm in association with F-actin, and in the nucleus where it binds chromatin. The normal function of c-Abl is poorly understood. Nevertheless, there has been rapid progress in the characterization of the structural features,
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Tyrosine Kinases and Inflammatory Signalling

Current Molecular Medicine, 2009
The activity of tyrosine kinases is central to many cellular processes, and accumulating evidence suggests that their role in inflammation is no less profound. Three main tyrosine kinase families, the Src, Tec and Syk kinase families are intimately involved in TLR signalling, the critical first step in cellular recognition of invading pathogens and ...
Theresa H, Page, Maria, Smolinska, Justin, Gillespie, Anna M, Urbaniak, Brian M J, Foxwell   +4 more
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Tyrosine kinase inhibitors and the thyroid

Best Practice & Research Clinical Endocrinology & Metabolism, 2009
Protein tyrosine kinase inhibitors (TKIs) have emerged as significant targets for novel cancer therapies. For patients with differentiated or medullary carcinomas unresponsive to conventional treatments, multiple novel therapies primarily targeting angiogenesis have entered clinical trials.
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Study of Tyrosine Kinases and Protein Tyrosine Phosphorylation

2004
In recent years, our increased understanding of the complex signal transduction mechanisms that regulate cellular function has fueled huge advances in all aspects of biomedical science and cell biology. Platelet and megakaryocyte function is no exception to this. In the last 10 yr our understanding of the receptor biochemistry and the systems that they
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Receptor tyrosine kinases and their targets

Current Opinion in Genetics & Development, 1994
One of the ways in which higher eukaryotes receive messages from the environment is via cell surface receptor tyrosine kinases. These are transmembrane proteins with an extracellular binding domain that specifies the growth factor with which it will interact, and an intracellular domain that encodes the tyrosine kinase.
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PROTEIN-TYROSINE KINASES

Annual Review of Biochemistry, 1985
T, Hunter, J A, Cooper
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The Viral Tyrosine Protein Kinases

1986
The acutely transforming retroviruses have revealed the existence of more than twenty different genes with oncogenic potential. Seven of these — src, abl, yes, erbB, fps (fes), fgr, fms, and ros — encode proteins with intrinsic tyrosine protein kinase activity.
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