Results 221 to 230 of about 871,767 (407)

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, EarlyView.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source

Evaluating the Effectiveness of Tyrosine Kinase Inhibitors on EGFR Mutations In Vitro. [PDF]

Int J Mol Sci
Shao H, Wells A.
europepmc   +1 more source

WSGC@FA@PEG/PEI‐SPIONs Mitigate Chemoresistance in Gastric Adenocarcinoma by Modulating the Notch Signaling Pathway and Mitophagy

Advanced Science, EarlyView.
WSGC peptide reverses drug resistance in GA by modulating the Notch signaling pathway and mitophagy at the molecular level. Abstract This study investigates the molecular mechanisms by which superparamagnetic iron oxide nanoparticles (SPIONs) loaded with the WSGC peptide (WSGC@FA@PEG/PEI‐SPIONs)—a 40‐amino acid polypeptide derived from apoC‐III ...
Dongjian Song, Qiuliang Liu, Zechen Yan, Qi Wang, Meng Su, Hui Zhang, Longyan Shi, Yingzhong Fan, Qian Zhang, Heying Yang, Da Zhang   +10 more
wiley   +1 more source

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

, 1998
David W. Fry, Alexander J. Bridges, William A. Denny, Annette M. Doherty, Kenneth D. Greis, James L. Hicks, Kenneth E. Hook, Paul R. Keller, Wilbur R. Leopold, Joseph A. Loo, Dennis J. McNamara, James M. Nelson, Veronika Sherwood, Jeff B. Smaill, Susanne Trumpp-Kallmeyer, Ellen M. Dobrusin   +15 more
openalex   +1 more source

Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor [PDF]

, 2000
William E. Sweeney, Yue-Gang Chen, Koichi Nakanishi, Philip Frost, Ellis D. Avner   +4 more
openalex   +1 more source

Tyrosine kinase – Role and significance in Cancer

International Journal of Medical Sciences, 2004
Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli.
doaj  

Tyrosine Kinase Inhibitors for Gastrointestinal Stromal Tumor After Imatinib Resistance. [PDF]

Pharmaceutics
Xiao XH, Zhang QS, Hu JY, Zhang YX, Song H.   +4 more
europepmc   +1 more source

POLE Deficiency Exacerbates Diesel Engine Exhaust‐Induced Genomic Instability and Malignant Transformation of Bronchial Epithelial Cells

Advanced Science, EarlyView.
This study establishes a diesel engine exhaust (DEE)‐induced malignant transformation model in bronchial epithelial cells. Whole genome sequencing（WGS） and RNA‐seq reveal DEE‐induced mutational signatures and gene expression profiles. Mechanistically, DEEaffect polymerase epsilon (POLE) and mismatch repair, driving genomic instability and promoting ...
Pimei Zhang, Zhaoxu Wu, Qiang Ju, Nuo Xu, Xian Chen, Hongguang Chen, Shuaishuai Yang, Jing Ji, Yanjie Zhao   +8 more
wiley   +1 more source

Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties

, 1998
Lisha Zhang, Yiu-Keung Lau, Larry Xi, Ruey‐Long Hong, Darrick S. H. L. Kim, Chieh‐Fu Chen, Gabriel N. Hortobagyi, Ching‐Jer Chang, Mien‐Chie Hung   +8 more
openalex   +1 more source

Overexpression of Protein-tyrosine Phosphatase-1B in Adipocytes Inhibits Insulin-stimulated Phosphoinositide 3-Kinase Activity without Altering Glucose Transport or Akt/Protein Kinase B Activation [PDF]

, 2000
Carol L. Venable, Ernst U. Frevert, Young‐Bum Kim, Britta Fischer, Shubhangi Kamatkar, Benjamin G. Neel, Barbara B. Kahn   +6 more
openalex   +1 more source