Results 251 to 260 of about 871,767 (407)

Integrative Omics Reveals Glutamine Catabolism‐Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading

Advanced Science, EarlyView.
This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Yi Ding, Fan Tong, Mingqiu Liu, Pin Yang, Jing Zeng, Yinghua Wei, Chunlin Li, Dong Li, Cheng Chang, Yangjun Zhang, Shaoqiong Yi, Fan Hu, Wenjie Shu, Lingqiang Zhang, Chun‐Ping Cui   +14 more
wiley   +1 more source

Tyrosine kinase inhibitors and cycloheximide inhibit Li+ protection of cerebellar granule neurons switched to non-depolarizing medium

, 1996
Sylvain Grignon, Nicolas Lévy, François Couraud, Bernard Bruguerolle   +3 more
openalex   +1 more source

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia [PDF]

, 2001
Brian J. Druker, Moshe Talpaz, Debra Resta, Bin Peng, Elisabeth Buchdunger, J. Ford, Nicholas Lydon, Hagop M. Kantarjian, Renaud Capdeville, Sayuri Ohno-Jones, Charles L. Sawyers   +10 more
openalex   +1 more source

MET tyrosine kinase inhibitors in combination with EGFR tyrosine kinase inhibitors in NSCLC patients with EGFR mutations and acquired MET alterations: a systematic review and meta-analysis. [PDF]

BMC Cancer
Hu D, Hu Y, Lei S, Wu D, Wang Y.
europepmc   +1 more source

Seizures and cancer: drug interactions of anticonvulsants with chemotherapeutic agents, tyrosine kinase inhibitors and glucocorticoids.

Neuro-Oncology Practice, 2016
C. Benit, C. Vecht
semanticscholar   +1 more source

The Evolutionary Trajectory and Prognostic Value of GITR+ Tregs Reprogramed by Tumor‐Intrinsic PD‐1/c‐MET Signaling in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), tumor‐intrinsic PD‐1 signaling activates the MET pathway, leading to the establishment of an immunosuppressive tumor microenvironment (TME). This MET‐driven signaling cascade promotes the selective accumulation of GITR+ regulatory T cells (Tregs), a highly immunosuppressive subset.
Jiande Han, Hanlin Yin, Taochen He, Junyi He, Zhenlai Jiang, Qiangda Chen, Zhihang Xu, Yuqi Xie, Yaolin Xu, Haibo Wang, Wenquan Wang, Wenchuan Wu, Yun Jin, Wenhui Lou, Jun Yu, Ning Pu, Liang Liu   +16 more
wiley   +1 more source

Lauryl Gallate Inhibits the Activity of Protein Tyrosine Kinase c-Src Purified from Human Platelets [PDF]

, 2001
Carmen Palacios, Constantino Cespón, Cristina Martín de la Vega, Garbiñe Roy, Antonio Serrano, Matilde Salinas, Pedro González-Porqué   +6 more
openalex   +1 more source

BCR::ABL1 Tyrosine Kinase Inhibitors During Pregnancy, a Disproportionality Analysis of Vigibase. [PDF]

Clin Pharmacol Ther
Cabannes-Hamy A, Kabirian R, Jochum F, Bihan K, Dumas E, Coussy F, Laas E, Rousselot P, Choquet S, Uzunov M, Salomon L, Reyal F, Hamy AS, Gougis P.   +13 more
europepmc   +1 more source

Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6

Advanced Science, EarlyView.
Extracellular matrix compliance plays a critical role in the regulation of integrin‐mediated adhesion and cell motility. Here, it is reported that strengthening the kindlin2‐integrin β6 interaction overcomes the dependence on extracellular substrate stiffness and promotes integrin β6‐mediated cell migration.
Wan Ning Lee, Jiamin Li, Nan‐Peng Chen, Cheng‐han Yu   +3 more
wiley   +1 more source

The Adverse Impact of Tyrosine Kinase Inhibitors on Wound Healing and Repair. [PDF]

Int Wound J
Nahm WJ, Falanga V.
europepmc   +1 more source