Results 251 to 260 of about 857,410 (384)

Tyrosine kinase inhibitors and cycloheximide inhibit Li+ protection of cerebellar granule neurons switched to non-depolarizing medium

, 1996
Sylvain Grignon, Nicolas Lévy, François Couraud, Bernard Bruguerolle   +3 more
openalex   +1 more source

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia [PDF]

, 2001
Brian J. Druker, Moshe Talpaz, Debra Resta, Bin Peng, Elisabeth Buchdunger, J. Ford, Nicholas Lydon, Hagop M. Kantarjian, Renaud Capdeville, Sayuri Ohno-Jones, Charles L. Sawyers   +10 more
openalex   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Bosutinib-Induced Pleural Effusion-Class Effect and Cross-Intolerance to All Tyrosine Kinase Inhibitors. [PDF]

Hematol Rep
Vojjala N, Sami HA, Kotla NK, Peshin S, Goyal K, Kondaveety S, Prabhu RR, Krishnamoorthy G.   +7 more
europepmc   +1 more source

The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls [PDF]

, 2001
Uwe‐Karsten Hanisch, Marco Prinz, Klemens Angstwurm, Karl Georg Häusler, Oliver Kann, Helmut Kettenmann, Joerg R. Weber   +6 more
openalex   +1 more source

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou, Meng Gao, Shikun Zhang, Wing‐Wa Guo, Wenzhi He, Minghe Zhang, Xi Chen, Cairang Dongzhi, Xiaomian Li, Yufeng Yuan, Weijie Ma   +10 more
wiley   +1 more source

Peripheral neuropathy in the phase 3 ASPEN study of Bruton tyrosine kinase inhibitors for Waldenström macroglobulinemia. [PDF]

Blood Adv
Heyman BM, Opat SS, Wahlin BE, Dimopoulos MC, Castillo JJ, Tedeschi A, Tam CS, Buske C, Owen RG, Leblond V, Trotman J, Barnes G, Chan WY, Schneider J, Allewelt H, Cohen A, Matous JV.   +16 more
europepmc   +1 more source

3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors Block Calcium-dependent Tyrosine Kinase Pyk2 Activation by Angiotensin II in Vascular Endothelial Cells [PDF]

, 2001
Kumi Satoh, Kazuo Ichihara, Erwin J. Landon, Tadashi Inagami, Hua Tang   +4 more
openalex   +1 more source

The Molecular Basis of Amino Acids Sensing

Advanced Science, EarlyView.
Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang, Xiao Tan, Jiali Jin, Ping Wang   +3 more
wiley   +1 more source

Anti-angiogenic tyrosine kinase inhibitors and the pathophysiology of their toxic effects: revisiting the treatment of anemia in metastatic cancers. [PDF]

Exp Hematol Oncol
Van Nguyen T, Angeli E, Hamdan D, El Bouchtaoui M, Bui OT, Azibani F, Shen R, Lu H, Do KH, Janin A, Van Le Q, Bousquet G.   +11 more
europepmc   +1 more source