Results 371 to 380 of about 871,767 (407)
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Tyrosine Kinase Inhibitors in Preclinical Development
Investigational New Drugs, 1999Due to the limited efficacy of cytotoxic chemotherapy in the treatment of advanced malignancy and its excessive toxicity precluding its use in chemoprevention, new therapeutic and preventive strategies have been sought. One of the most interesting of these new approaches is the manipulation of signal transduction pathways.
Patrick P. Koty, Mark L. Levitt
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Forthcoming receptor tyrosine kinase inhibitors
Expert Opinion on Therapeutic Targets, 2006Receptor tyrosine kinases play a significant role in carcinogenesis and have been successfully targeted with monoclonal antibodies and small-molecule inhibitors. There have been recent developments in the understanding of receptor tyrosine kinase signal transduction which have enabled better drug development.
Ezra E.W. Cohen, Nicholas W. Choong
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Clinical pharmacokinetics of tyrosine kinase inhibitors
Cancer Treatment Reviews, 2009In the recent years, eight tyrosine kinase inhibitors (TKIs) have been approved for cancer treatment and numerous are under investigation. These drugs are rationally designed to target specific tyrosine kinases that are mutated and/or over-expressed in cancer tissues.
Henk-Jan Guchelaar +2 more
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Small molecule tyrosine kinase inhibitors in glioblastoma
Archives of pharmacal research, 2020Gayoung Kim, Y. Ko
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Are Tyrosine Kinase Inhibitors the Better Serotonin Inhibitors?
American Journal of Respiratory and Critical Care Medicine, 2013Ralph T. Schermuly, Djuro Kosanovic
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Long-Term Side Effects of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
Current Hematologic Malignancy Reports, 2016Lauren E. Caldemeyer +3 more
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Hepatotoxicity of tyrosine kinase inhibitors
Toxicology Letters, 2015F. Paech +2 more
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Drug–drug interactions in patients receiving tyrosine kinase inhibitors
Journal of Oncology Pharmacy Practice, 2018Kristine L Keller +3 more
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