Results 191 to 200 of about 1,485,018 (348)

Tyrosine phosphorylation of the scaffold protein IQGAP1 by VEGFR2 modulates cell proliferation. [PDF]

J Biol Chem
Babu Sait MR, Li Z, Thines L, Wang T, Zappacosta F, Annan RS, Sacks DB.   +6 more
europepmc   +1 more source

Tyrosine Phosphorylation and Proteolysis [PDF]

Journal of Biological Chemistry, 1998
Manuela Vecchi, Laura A. Rudolph-Owen, Christa L. Brown, Peter J. Dempsey, Graham Carpenter   +4 more
openaire   +1 more source

Tyrosine phosphorylation in the human duodenum.

, 1995
peer-reviewedMany growth factor receptors including the epidermal growth factor receptor function through tyrosine kinase activity. The aim of this study was to examine the constitutive level of tyrosine phosphorylation in the normal duodenum and in the ...
KELLEHER, DERMOT P, SHEILS, ORLA
core  

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source

Neurotensin Receptor 1 Regulates HER4 Tyrosine Phosphorylation in Lung Cancer Cells. [PDF]

Biology (Basel)
Moody TW, Ramos-Alvarez I, Jensen RT.
europepmc   +1 more source

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

Advanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri, Boobash Raj Selvadurai, Nitin Gupta, Arturo Simoni‐Nieves, Alessandro Genna, Moshit Lindzen, Rishita Chatterjee, Marieke Van Daele, Deepthi Ramesh Kumar, Mirie Zerbib, Roni Oren, Isabelle Sophie Meijer, Elisabeth Franziska Wippich, Yahel Avraham, Rony Dahan, Yuya Haga, Laura E. Kilpatrick, Simon Platt, Stephen J. Hill, Lipika R. Pal, Eytan Ruppin, Yasuo Tsutsumi, Eliane Hadas Yardeni, Muhammad Abu Ahmad, Olga Radinsky, Donatella Romaniello, Mattia Lauriola, Angel Porgador, Yosef Yarden   +28 more
wiley   +1 more source

Tributyltin chloride-induced effects on protein tyrosine phosphorylation and on extracellular-signal-regulated kinase (ERK) phosphorilation in Ascidian Phallusia mammilata

, 2011
Ascidians represent an intriguing candidate experimental system for studying the effects of environmental stress. We studied TBT effects and probable related pathways were investigated on ascidian embryos by using Western immunoblotting.
DOLCEMASCOLO, Giuseppe, GIANGUZZA, Mario, DAMIANI, Francesca   +2 more
core  

Small-Molecule-Mediated Depletion of the Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1B (DYRK1B) Protein Scaffold. [PDF]

ACS Pharmacol Transl Sci
Ems M, Lindberg MF, Adhikary T, Meijer L, Lauth M.   +4 more
europepmc   +1 more source

Pyruvate Kinase M2‐Mediated H3K9 Lactylation and XBP1 Signaling Positive Feedback Loop Facilitates CD4+ T Cell Spinal Recruitment and Central Sensitization in Rheumatoid Arthritis

Advanced Science, EarlyView.
In collagen‐induced arthritis (CIA) mice, increased CD4+ T cell accumulation in the spinal dorsal horn induces pain hypersensitivity. Mechanistically, PKM2‐mediated H3K9 lactylation and XBP1 signaling positive feedback loop facilitates CD4+ T cell spinal migration and induces central sensitization‐like behaviors in CIA mice.
Yuepeng Jiang, Xiaoxuan Zhao, Xiao Ma, Mengjia Zheng, Junjun Wen, Yujie Li, Yue Wu, Yun Zhang, Jie Yu, Charles R. Ashby Jr, Chengping Wen   +10 more
wiley   +1 more source

Tyrosine phosphorylation coupling of one-carbon metabolism and virulence in an endogenous pathogen. [PDF]

Proc Natl Acad Sci U S A
Stocke KS, Pandey SD, Jin S, Perpich JD, Yakoumatos L, Kosaki H, Wilkey DW, Fitzsimonds ZR, Vashishta A, Snider I, Sriwastva MK, Li H, Jin JZ, Miller DP, Merchant ML, Bagaitkar J, Uriarte SM, Potempa J, Lamont RJ.   +18 more
europepmc   +1 more source