Results 211 to 220 of about 1,485,018 (348)

STUDIES ON THE PHOSPHORYLATION OF TYROSINE HYDROXYLASE

, 1984
Tyrosine hydroxylase (E.C. 1.14.16.2, L-tyrosine tetrahydropteridine:oxygen oxidoreductase, 3-hydroxylating), is the initial and rate limiting enzyme in the biosynthetic pathway of catecholamine production. The mechanism by which the activity of tyrosine
GEORGE, ROBERT JAMES
core  

TIPIN Couples Epigenetic Rewiring to EGFR Stabilization and Lenvatinib Resistance in Liver Cancer

Advanced Science, EarlyView.
DNA hypomethylation elevates TIPIN expression in liver cancer. TIPIN competes with E3 ligase c‐Cbl for the EGFR intracellular domain, inhibiting EGFR ubiquitination and lysosomal degradation to sustain oncogenic EGFR‐ ERK signaling. High TIPIN confers lenvatinib resistance, while TIPIN depletion restores drug sensitivity in liver cancer. ABSTRACT Aims:
Xing Jia, Shiyu Zhang, Yangbo Tang, Shinuo Chen, Xingxin Zhu, Junran Chen, Suchen Bian, Lei Zheng, Chi Zhang, Haojing Ma, Wengfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Qinglin Li, Penghong Song   +15 more
wiley   +1 more source

Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase

, 1997
Gamma interferon (IFN-γ) induces both tyrosine and serine phosphorylation of Stat1. Stat1 serine phosphorylation is required for maximal transcriptional activity of Stat1.
Wen, Zilong, Darnell, James E., Zhu, Xuejun, Xu, Liang Zhong   +3 more
core  

Dual Suppression of Oxidative Stress and JAK/STAT3 Signaling Attenuates Inflammation‐Driven Corneal Neovascularization

Advanced Science, EarlyView.
Corneal neovascularization is sustained by oxidative stress and inflammatory STAT3 signaling. A macrophage membrane‐cloaked nanozyme, Sta@MSR, combines ruthenium‐mediated ROS scavenging with Stattic‐mediated STAT3 inhibition. Delivered as eye drops, Sta@MSR enhances ocular retention and corneal penetration, reduces inflammatory and angiogenic responses,
Qinghua Li, Ruoxi Li, Bingxin Ren, Chaoya Gong, Hui Yan, Jie Chen, Benzhao Fu, Chaoqun Wei, Qingdong Bao, Yang Li, Xiaoxue Liu, Wenlong Li, Hua Gao   +12 more
wiley   +1 more source

FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylation. [PDF]

Nat Commun
Chuykin I, Sokol SY.
europepmc   +1 more source

LepR‐Lineage Cells Represent the Main Target of the Nociceptive CGRP Pathway in White Adipose Tissue Browning

Advanced Science, EarlyView.
Regulation of WAT Browning and UCP1 Expression in LepR‐MSCs of Inguinal WAT by Nociceptive CGRP and Sympathetic Nervous System (SNS) Noradrenaline (NE). ABSTRACT Sympathetic innervation regulates white adipose tissue (WAT) browning; however, the roles of nociceptive neurons and their associated target cells remain unknown.
Yu‐Ting Yen, May Chien, Yan‐Tung Kiu, Ru‐Sing Lee, Hui‐Teng Cheng, Shuei‐Liong Lin, Dong‐Chuan Wu, I‐Hsien Teng, Yi‐Wen Lin, Yi‐Hung Chen, Mien‐Chie Hung, Shih‐Chieh Hung   +11 more
wiley   +1 more source

ABL1-mediated tyrosine phosphorylation of SYCP2 contributes to transcription-coupled homologous recombination and platinum resistance in ovarian cancer. [PDF]

NAR Cancer
Gao B, Wang X, Long M, Zhang F, Wang Y, Kumar R, Veillard I, Rueda BR, Yeku O, Lan L.   +9 more
europepmc   +1 more source

Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase inhibitor.

Genes & Development, 2011
Y. Jaillais, M. Hothorn, Youssef Belkhadir, T. Dabi, Zachary L. Nimchuk, E. Meyerowitz, J. Chory   +6 more
semanticscholar   +1 more source

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics (GFCH)

American Journal of Hematology, EarlyView.
ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse   +16 more
wiley   +1 more source

Enhanced ADP-heptose-dependent NF-κB activation by Helicobacter pylori CagA through cortactin-Src-dependent tyrosine phosphorylation of IKKβ. [PDF]

Microlife
Sharafutdinov I, Tegtmeyer N, Friedrich B, Naumann M, Backert S.   +4 more
europepmc   +1 more source