Animal Research and One Health, EarlyView.Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren +6 more
wiley +1 more source
Reduced nephrin tyrosine phosphorylation impairs podocyte force transmission and accelerates detachment in disease. [PDF]
iScienceWilliamson CR +9 more
europepmc +1 more source
Animal Research and One Health, EarlyView.Multifunctional roles of functional amino acids in regulating meat quality in ruminants: Functional amino acids (FAAs) regulate ruminant meat quality through multiple interconnected mechanisms, including antioxidant protection, metabolic regulation, signal transduction, structural support, and gene expression modulation.
Zixin Liu +5 more
wiley +1 more source
Focal adhesion kinase/Src family kinase axis-mediated tyrosine phosphorylation of metabolic enzymes facilitates tumor metastasis. [PDF]
Signal Transduct Target TherChen J +7 more
europepmc +1 more source
Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis
Arthritis &Rheumatology, EarlyView.Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm +2 more
wiley +1 more source
Tyrosine phosphorylation of Kir6.2 subunit negatively regulates cardiac K<sub>ATP</sub> channel activity. [PDF]
Basic Res CardiolZhi Y +7 more
europepmc +1 more source
IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis
Arthritis &Rheumatology, EarlyView.Objective Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. IgG from patients with LN displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay +3 more
wiley +1 more source
Distinct VE-cadherin serine and tyrosine phosphorylation sites and their role for inflammation-induced vascular permeability in vivo. [PDF]
Cell Mol Life SciHoltermann L +5 more
europepmc +1 more source
Spatial Proteomics Identifies Distinct Synovial Microenvironments in Hip and Knee Osteoarthritis
Arthritis &Rheumatology, Accepted Article.Objective Osteoarthritis (OA) is a heterogeneous joint disease, yet mechanistic insights derive predominantly from knee OA and are often extrapolated to other joints. We investigated joint‐associated differences in the spatial molecular organization of hip and knee OA synovium.
Peng Xie +9 more
wiley +1 more source