Results 241 to 250 of about 1,485,018 (348)

Label-Free SERS Sensors for Real-Time Monitoring of Tyrosine Phosphorylation. [PDF]

Anal Chem
Geddis A, Mendive-Tapia L, Sujantho A, Liu E, McAughtrie S, Goodwin R, Vendrell M, Campbell CJ.   +7 more
europepmc   +1 more source

Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia

Journal of Cell Science, 2010
Matthew G. Oser, Christopher C. Mader, H. Gil-Henn, Marco A. O. Magalhaes, J. Bravo-Cordero, A. Koleske, J. Condeelis   +6 more
semanticscholar   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

ARRDC3 tyrosine phosphorylation functions as a switch to control c-Src versus WWP2 interactions and distinct scaffolding functions. [PDF]

J Biol Chem
Caplan M, Bardeleben C, Dhawan K, Plawat R, Kufareva I, Trejo J.   +5 more
europepmc   +1 more source

Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

Proceedings of the National Academy of Sciences of the United States of America, 2002
H. Higashi, Ryouhei Tsutsumi, A. Fujita, S. Yamazaki, M. Asaka, T. Azuma, M. Hatakeyama   +6 more
semanticscholar   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Discovery of a selective dual-specificity tyrosine phosphorylation-regulated kinase 1B inhibitor with anti-adipogenic and anti-diabetic activities. [PDF]

Front Pharmacol
Kang S, Na YJ, Choi KJ, Jung WH, Park A, Im J, Park SB, Koh B, Lee JY, Hoe KL, Kim HJ, Shin SJ, Lee H, Kim KY.   +13 more
europepmc   +1 more source

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions

Journal of Cell Science, 2006
R. Zaidel-Bar, R. Milo, Z. Kam, B. Geiger   +3 more
semanticscholar   +1 more source

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source