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Role of Tyrosine Phosphorylation in PTP–PEST
The Journal of Physical Chemistry B, 2023We study the influence of tyrosine phosphorylation on PTP-PEST, a cytosolic protein tyrosine phosphatase. Utilizing a combination of experimental data and computational modeling, specific tyrosine sites, notably Y64 and Y88, are identified for potential phosphorylation.
T S Sreevidya +4 more
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1996
Abstract 1. A role for tyrosine phosphorylation in signal transduction One of the central questions in cell biology is how do cells communicate with each other and their environment, and how does an individual cell regulate itself? Characterization of the proteins that regulate extracellular and intracellular signal transduction has lead
Edwin A Clark, Joans. Brugge
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Abstract 1. A role for tyrosine phosphorylation in signal transduction One of the central questions in cell biology is how do cells communicate with each other and their environment, and how does an individual cell regulate itself? Characterization of the proteins that regulate extracellular and intracellular signal transduction has lead
Edwin A Clark, Joans. Brugge
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Tyrosine phosphorylation in human neutrophil
Biochemical and Biophysical Research Communications, 1989Protein tyrosine phosphorylation in human neutrophils was examined by immunoblotting with antibodies specific for phosphotyrosine. The addition of the human hormone granulocyte-macrophage colony stimulating factor to human neutrophils caused an increase in the tyrosine phosphorylation levels of several proteins.
J, Gomez-Cambronero +6 more
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Tyrosine phosphorylation in plant bending
Nature, 2000Puckering in a ticklish plant is controlled by dephosphorylation of its actin. The phosphorylation of the amino acid tyrosine in animal proteins acts as an on–off switch in numerous pathways that regulate growth, differentiation and oncogenesis1,2. In the unicellular slime mould Dictyostelium , tyrosine-phosphorylation of actin controls cell-shape ...
K, Kameyama +5 more
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Tyrosine phosphorylation in Escherichia coli
Journal of Molecular Biology, 1998The phosphorylation on tyrosine of a protein in Escherichia coli both in vivo and in vitro was revealed by recognition by anti-phosphotyrosine antibodies, labelling with [gamma-32P]ATP, and phosphoamino acid analysis. This protein, which we name TypA, is the product of the o591 reading frame as revealed by N-terminal sequencing and antibody cross ...
Freestone, P +4 more
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Conformational Clusters of Phosphorylated Tyrosine
Journal of the American Chemical Society, 2017Tyrosine phosphorylation plays an important role in many cellular and intercellular processes including signal transduction, subcellular localization, and regulation of enzymatic activity. In 1999, Blom et al., using the limited number of protein data bank (PDB) structures available at that time, reported that the side chain structures of ...
Maha Abdelrasoul +6 more
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A Luminescent Sensor for Tyrosine Phosphorylation
Organic Letters, 2007We have developed a luminogenic probe for tyrosine phosphorylation based on a short peptide sequence containing an iminodiacetate moiety near the site of phosphorylation. In response to kinase activity, the probe provides a strong luminescence enhancement, resulting from the increased ability of the probe to bind and sensitize Tb3+ and Eu3+ ions upon ...
Matthew S, Tremblay +2 more
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Protein phosphorylation on tyrosine in bacteria
Archives of Microbiology, 2004Protein phosphorylation on tyrosine has been demonstrated to occur in a wide array of bacterial species and appears to be ubiquitous among prokaryotes. This covalent modification is catalyzed by autophosphorylating ATP-dependent protein-tyrosine kinases that exhibit structural and functional features similar, but not identical, to those of their ...
Cozzone, Aj +3 more
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Tyrosine phosphorylation of plant tubulin
Planta, 2008Phosphorylation of alphabeta-tubulins dimers by protein tyrosine kinases plays an important role in the regulation of cellular growth and differentiation in animal cells. In plants, however, the role of tubulin tyrosine phosphorylation is unknown and data on this tubulin modification are limited.
Yaroslav, Blume +6 more
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Nuclear tyrosine phosphorylation: the beginning of a map [PDF]
Biochemical Pharmacology, 2000 Tyrosine phosphorylation is usually associated with cytoplasmic events. Yet, over the years, many reports have accumulated on tyrosine phosphorylation of individual molecules in the nucleus, and several tyrosine kinases and phosphatases have been found ...
Giulio Superti-Furga +2 more
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