Results 301 to 310 of about 1,485,018 (348)
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A Luminescent Sensor for Tyrosine Phosphorylation
Organic Letters, 2007We have developed a luminogenic probe for tyrosine phosphorylation based on a short peptide sequence containing an iminodiacetate moiety near the site of phosphorylation. In response to kinase activity, the probe provides a strong luminescence enhancement, resulting from the increased ability of the probe to bind and sensitize Tb3+ and Eu3+ ions upon ...
Matthew S, Tremblay +2 more
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Protein phosphorylation on tyrosine in bacteria
Archives of Microbiology, 2004Protein phosphorylation on tyrosine has been demonstrated to occur in a wide array of bacterial species and appears to be ubiquitous among prokaryotes. This covalent modification is catalyzed by autophosphorylating ATP-dependent protein-tyrosine kinases that exhibit structural and functional features similar, but not identical, to those of their ...
Cozzone, Aj +3 more
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Tyrosine phosphorylation of plant tubulin
Planta, 2008Phosphorylation of alphabeta-tubulins dimers by protein tyrosine kinases plays an important role in the regulation of cellular growth and differentiation in animal cells. In plants, however, the role of tubulin tyrosine phosphorylation is unknown and data on this tubulin modification are limited.
Yaroslav, Blume +6 more
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Tyrosine Phosphorylation of Rab Proteins
2005Tyrosine phosphorylation is a fundamental mechanism for regulating the functions of numerous proteins in eukaryotic cells. It has been known for some time that several members of the Rab GTPase family can undergo phosphorylation on serine or threonine residues, but the potential for tyrosine phosphorylation has been appreciated only recently, based on ...
Jean H, Overmeyer, William A, Maltese
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Study of Tyrosine Kinases and Protein Tyrosine Phosphorylation
2004In recent years, our increased understanding of the complex signal transduction mechanisms that regulate cellular function has fueled huge advances in all aspects of biomedical science and cell biology. Platelet and megakaryocyte function is no exception to this. In the last 10 yr our understanding of the receptor biochemistry and the systems that they
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Regulation of Tyrosine Kinases by Tyrosine Phosphorylation
1991Protein kinases can be classified according to whether they phosphorylate phenolic (tyrosine) or aliphatic (serine and threonine) hydroxyl groups (Hunter and Cooper, 1985). Although there are now a few examples of kinases that seemingly break the rule (Howell et al., 1990), most tyrosine kinases differ from the serine/threonine kinases in their primary
Jonathan A. Cooper +2 more
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Negative Regulation of a Protein Tyrosine Phosphatase by Tyrosine Phosphorylation
Journal of the American Chemical Society, 2006The low molecular weight protein tyrosine phosphatase (LMW-PTP) is a ubiquitously expressed enzyme with several proposed roles in cell signaling. Previously, two tyrosine phosphorylation modifications of LMW-PTP at sites Tyr-131 and Tyr-132 in response to growth factor stimulation have been mapped and suggested to stimulate LMW-PTP phosphatase activity.
Dirk, Schwarzer +3 more
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A Quantitative Assay for Tyrosine Sulfation and Tyrosine Phosphorylation in Peptides
Biological Chemistry Hoppe-Seyler, 1990A method was developed to measure sulfation and phosphorylation of tyrosine in proteins after alkaline hydrolysis, ion-exchange chromatography, reaction with [3H]dinitrofluorobenzene and subsequent thin-layer chromatography. The method allows the detection of 10-20 pmol of modified tyrosine and was applied to determine the content of tyrosine-phosphate
H, Blode, T, Heinrich, H, Diringer
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Phosphorylation of tyrosine in cultured human placenta
Biochimica et Biophysica Acta (BBA) - General Subjects, 1983The [32P]phosphoamino acids in proteins of first trimester and term-cultured human placentas have been separated and their relative amounts were measured. A significant phosphorylation of tyrosine residues could be detected in the cultured placental tissue at different stages of gestation.
H, Galski +3 more
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