Results 71 to 80 of about 3,205 (146)

Recent Advancements in Known and Emerging Risk Factors of Hepatocellular Carcinoma

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer‐related deaths worldwide. Despite advancements in antiviral therapies for hepatitis B (HBV) and hepatitis C (HCV), HCC incidence continues to rise due to metabolic dysfunction‐associated steatotic liver disease (MASLD), obesity ...
Muhammad Masroor Hussain, Bi Feng, Ju‐Mei Wang, Ao‐Qiang Zhai, Fu‐yu Li, Hai‐jie Hu   +5 more
wiley   +1 more source

Inter‐laboratory analytical improvement of succinylacetone and nitisinone quantification from dried blood spot samples

JIMD Reports, 2020
Background Nitisinone is used to treat hereditary tyrosinemia type 1 (HT‐1) by preventing accumulation of toxic metabolites, including succinylacetone (SA). Accurate quantification of SA during newborn screening is essential, as is quantification of both
Hilde Laeremans, Charles Turner, Tommy Andersson, Jose Angel Cocho deJuan, Adam Gerrard, M. Rebecca Heiner‐Fokkema, Diran Herebian, Nils Janzen, Giancarlo laMarca, Mattias Rudebeck   +9 more
doaj   +1 more source

Techno‐Functional Properties and Pharmaceutical Potential of Jackfruit Peel, Pulp, and Seeds

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
FTIR showed that the pulp had the highest number of peaks. 8 volatile compounds were present in different percentages in the three samples. ABSTRACT Jackfruit contains a significant quantity of secondary metabolites that are classified as high‐value biological compounds.
Stéphano Tambo Téné, Donald Sévérin Dangang Bossi, François Zambou Ngoufack, Venkatachalapathy Natarajan   +3 more
wiley   +1 more source

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, Volume 3, Issue 6, November 2025.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

Evaluation of pre-symptomatic nitisinone treatment on long-term outcomes in Tyrosinemia type 1 patients: a systematic review

Orphanet Journal of Rare Diseases, 2017
Background Tyrosinemia type 1 (TYR1) is a rare autosomal recessive disorder of amino acid metabolism that is fatal without treatment. With medication (nitisinone) and dietary restrictions outcomes are improved.
Julia Geppert, Chris Stinton, Karoline Freeman, Hannah Fraser, Aileen Clarke, Samantha Johnson, Paul Sutcliffe, Sian Taylor-Phillips   +7 more
doaj   +1 more source

Supplemental technologies of liver ultrasound investigation at the 1-st type tyrosinemia in pediatrics

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2015
Aim of investigation. To carry out objective estimation of liver parenchyma state in children with the 1-st type hereditary tyrosinemia (НТ-1) by ultrasound method with quantitative estimation of hepatic parenchyma pattern.Material and methods.
G. M. Dvoryakovskaya, S. A. Ivleva, I. V. Dvoryakovsky, S. I. Polyakova   +3 more
doaj  

Tyrosinemia type 1: a case report

Бюллетень медицинских интернет-конференций, 2015
We report a case of a 2-month-old girl with tyrosinemia type 1 presented with dyspnea, fever, diarrea and hepatosplenomegalia.
Doronina A., Nadrah Mossa, Korovina O., Ovsyannikov D.   +3 more
openaire   +1 more source

LEFT LOBE LIVER TRANSPLANTATION FROM AB0-INCOMPATIBLE LIVING DONOR WITH SITUS INVERSUS

Вестник трансплантологии и искусственных органов, 2014
Situs inversus is a rare congenital abnormality that affects approximately 0.005% of all live births. Traditionally, this condition is considered as a contraindication for liver donation, primarily due to the peculiarities of the vascular anatomy and the
S. V. Gautier, O. M. Tsiroulnikova, D. G. Akhaladze, A. R. Monakhov, Kh. M. Khizroev, I. E. Tsiroulnikova, S. V. Meshcheryakov, T. A. Dzhanbekov, G. A. Saranov, N. N. Abramova   +9 more
doaj   +1 more source

Hereditary Tyrosinemia Type 1: Success and Challenges in Indian Subcontinent

Indian Pediatrics
To analyze the profile and outcomes of Indian children with hereditary tyrosinemia type 1 (HT-1).In this retrospective study, the data of children with a confirmed diagnosis of HT-1 from 2013 to 2024 admitted in the pediatric hepatology unit of a tertiary care referral center were analyzed.Eighteen children with HT-1 with a median (Q1, Q3) age of ...
Samannay Das, Vikrant Sood, Bikrant Bihari Lal, Rajeev Khanna, Seema Alam, Chhagan Bihari   +5 more
openaire   +2 more sources

Goldenhar syndrome and hereditary tyrosinemia type 1.

Saudi medical journal, 2006
We report a case of Goldenhar syndrome and hereditary tyrosinemia type 1 (HTT1), to our knowledge an association not previously described. This case further increases the diversity of observations and clinical descriptions of patients with this complex syndrome. We discuss pathogenetic aspects, and demonstrate further evidence of the effectiveness of 2-
Moeen A, Al-Sayed, Ali M, Al-Asmari, Mohammed S, Rashed   +2 more
openaire   +2 more sources