Results 91 to 100 of about 4,877,471 (257)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Neoproterozoic to early Paleozoic extensional and compressional history of East Laurentian margin sequences:the Moine Supergroup, Scottish Caledonides [PDF]

, 2014
This work was in part supported by Natural Environment Research Council grant NE/J021822/1, National Science Foundation grant EAR-0087650, and funds from our respective institutions.Neoproterozoic siliciclastic-dominated sequences are widespread along ...
Merle, Renaud, Millar, I.L., Connelly, J.N., Loewy, Staci L., Strachan, R.A., Nemchin, Alexander A., Nemchin, Alexander, Millar, Ian L., Dalziel, I.W., Merle, Renaud E.,, Cawood, Peter A., Loewy, S.L., Merle, Renaud E., Connelly, James N., Dalziel, Ian W.D., Cawood, P., Connelly, James, Jourdan, Fred, Dalziel, Ian W. D., Kinny, Peter, Kinny, Peter D., Strachan, Robin A.   +21 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A POTENTIAL EARLY PROTEROZOIC ZIRCON REFERENCE MATERIAL BAI-1-2023 FOR IN SITU U-Pb DATING

Геодинамика и тектонофизика
This study presents U-Pb dating results for zircon collected from the beaches of recreation zone "Peschanaya" (Sandy) on Lake Baikal. These beaches are formed exclusively by the erosion of Early Proterozoic rapakivi granites from the Primorsky Complex ...
A. V. Ivanov, N. V. Bryansky, U. S. Efremova, E. A. Gladkochub, A. A. Karimov, E. I. Demonterova, E. A. Mikheeva, Yu. D. Shcherbakov, A. S. Dubenskiy, V. S. Sheshukov, K. G. Erofeeva, O. I. Okina, V. B. Khubanov, D. V. Semenova, A. V. Karpov, N. V. Rodionov, V. G. Davydov, A. N. Larionov, S. L. Votyakov, M. V. Chervyakovskaya, V. S. Chervyakovsky, E. A. Pankrushina, D. A. Mandrygina, A. V. Kulikova, K. R. Minnebaev, L.-L. Zhang, N. M. Kudryashov   +26 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Simultaneous Determination of U-Pb Age and Trace Elements of Zircon by Laser Ablation Sector Field Inductively Coupled Plasma-Mass Spectrometry

Yankuang ceshi
Laser ablation sector field inductively coupled plasma-mass spectrometry (LA-SF-ICP-MS) is widely applied in U-Pb dating of zircon due to its remarkable sensitivity.
Linghao ZHAO, Dongyang SUN, Mingyue HU, Jihai YUAN, Chenzi FAN, Xiuchun ZHAN   +5 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source