Results 121 to 130 of about 163,795 (290)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
U-Pb dating for zircons from granitic rocks in southwestern Cambodia. [PDF]
Heliyon, 2023 Uchida E +6 more
europepmc +1 more source
U-Th-Pb isotopic systematics of lunar meteorite Asuka-31 [PDF]
, 1992 U-Th-Pb isotopic systematics indicate that Asuka-31 is of lunar origin and was formed 3940±8Ma. The Pb isotopic composition is extremely nonradiogenic compared with those of typical Apollo mare basalts. The Pb-Pb, U-Pb, and Th-Pb ages are concordant at 3.
Keiji Misawa +2 more
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Earthtime Lesson Plan for U/Pb Dating (grade 8-12) [PDF]
The Earthtime Lesson Plan is a complete description of a radiometric dating module taught to high school students at MIT. U/Pd dating and it's uses, teacher background, materials needed, time frame and National Science Standards are all provided as well ...
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Литосфера, 2019 Ильмено-Вишневогорский комплекс (ИВК) - один из крупнейших щелочных комплексов миаскитов, фенитов и карбонатитов с РЗЭ-Zr-Nb минерализацией, расположенный в Уральском складчатом поясе.
doaj
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Литосфера, 2020 The article covers the U-Pb dating of minerals belonging to the pyrochlore group from the rare-metal ore deposits of Ilmeny-Vishnevogorsky carbonatite-miaskite complex (South Urals). Individual pyrochlore crystals were dated through a new technique of in-
I. L. Nedosekova +5 more
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